Breaking Away From the Ivory Tower
Objective: We describe the evolution of the Geriatric Flying Squad (GFS), a rapid response outreach team for residential aged care facilities (RACFs) in the local…Disease Monitoring through the PKAN Disease Rating Scale (PKAN-DRS) in Pantothenate Kinase-Associated Neurodegeneration (PKAN)
Objective: To assess the utility of PKAN-DRS as an outcome measure for monitoring disease progression in PKAN . Background: The PKAN-DRS assess multiple domains affected…Oligodendrocyte-specific mRNA therapy with lipid nanoparticles
Objective: To develop lipid nanoparticles with high efficiency and specificity to introduce mRNA into oligodendrocytes. To denmonstrate the potential therapy of Krabbe disease as one…Archimedes spiral based non-linear regression machine learning model for predicting tremor’s severity
Objective: To predict tremor severity using the Archimedes spiral drawing, a commonly used item in tremor assessment scales. Background: The Archimedes spiral is widely used…Multimodal and Agentic Simulated AI Patients for Bridging the gap in Parkinson Disease Education
Objective: To develop an AI training platform in PD counseling that utilizes real-time NLP processing, multimodal inputs/outputs, and adaptive reinforcement learning supported by immediate feedback…A Randomized, Double-blind Phase 3 Trial of Amlenetug Versus Placebo in Patients with MSA: The MASCOT Trial
Objective: Describe the protocol for a randomized, double-blind phase 3 trial evaluating the efficacy and safety of amlenetug versus placebo in slowing clinical progression in…Effects of transcutaneous periodic vibratory stimulation on gait and balance function in Spinocerebellar degeneration -a pilot study
Objective: The aim of this study is to clarify the efficacy of transcutaneous periodic vibrational stimulation(TPVS)on gait and balance function in patients with spinocerebellar degeneration…Clinical case of Sporadic adult-onset ataxia
Objective: To describe a clinical case of Sporadic adult-onset ataxia(SAOA) Background: Sporadic ataxia in adults is a heterogeneous neurological condition characterized by progressive impairment of…Refractory Orthostatic Hypotension, Anterocollis Predominant Cervical Dystonia and Parkinsonism Associated with a Previously Undiscovered SYT14 Gene Mutation
Objective: We present a case of a patient with spinocerebellar ataxia symptoms associated with a previously unknown mutation of the SYT14 gene. Background: Spinocerebellar ataxias…Retrospective Analysis of our Supportive Care Clinic and Lifestyle Improvement Fitness Program
Objective: The Supportive Care Clinic and Lifestyle Improvement Fitness (LIFT) program provides multidisciplinary care and online educational resources for our parkinsonian patients. Demographics of patients…
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