Levodopa-entacapone-carbidopa intestinal gel in Parkinson’s disease – A randomized, crossover infusion study
Objective: To compare the systemic levodopa exposure during administration of levodopa-entacapone-carbidopa (LECIG) intestinal gel with levodopa-carbidopa intestinal gel (LCIG) in advanced Parkinson's disease (PD) patients.…Diurnal variation of levodopa plasma concentration in patients with Parkinson’s disease
Objective: We analyzed diurnal variation of levodopa plasma concentration in large number of patients with Parkinson's disease (PD) to clarify the pattern of diurnal variation.…Parkinson patient reported outcomes of voice and communication pre, post and 6 months following LSVT LOUD® and LSVT ARTIC
Objective: To evaluate the functional impact of LSVT LOUD and LSVT ARTIC on voice and communication in individuals with Parkinson's disease (PD) immediately post and…Preclinical evaluation of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesias: Is it a ‘chemical’ DBS?
Objective: To evaluate mechanism of long-term activity of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesias (LID). Background: Ketamine is an anesthetic that, when administered as…Utilization and longitudinal impact of anticholinergic use in Parkinson’s disease. National Parkinson Foundation (NPF) QII registry
Objective: To evaluate baseline predictors and longitudinal impact of anticholinergics use in Parkinson's disease (PD). Background: Anticholinergics have beneficial effect on tremor in PD but…ND0701: A novel safe concentrated apomorphine formulation for continuous subcutaneous administration via a patch pump
Objective: To characterize the local safety and PK of a novel apomorphine formulation, ND0701, in comparison to a commercially available apomorphine–HCl solution. Background: Apomorphine is…The Luxembourg Parkinson’s study: Integrating the Lewy body composite risk score into a longitudinal study
Objective: To validate the LBCRS in a longitudinal national cohort study. The Lewy Body Composite Risk ScorePlease rate the following physical findings being present or…Feasibility of implementing a long-term mobile device program in PD patients
Objective: To evaluate the feasibility of Parkinson's patients utilizing the Fox Insight Wear smartphone application in an environment outside the clinic. Background: A reliable quantitative…Establishment of InMotion, an independent, fee-free community center for persons with movement disorders
Objective: To describe the establishment of a community center, InMotion (IM), for persons with movement disorders. Background: Needs of people with movement disorders grow with…Falls and frailty predicate escalating care needs in Parkinson’s disease
Objective: Assess the prevalence of falls in Parkinson's disease and evaluate change in care needs and institutionalisation in this cohort over a 5 year follow-up…
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