2026 International Congress » Parkinson's Disease: Genetics

A Cumulative Genetic Risk Score Predicts Progression in Parkinson’s Disease: 5-year longitudinal study from The Early Parkinson’s disease Longitudinal Singapore (PALS) cohort

DX. Deng, LT. Tan, TEK. Tan (Singapore, Singapore)

A Genome-Wide Search for Common Variants Modifying Age at Onset in PRKN-Associated Parkinson’s Disease

PJ. Menon, C. Tesson, F. Casse, M. Ferrien, F. Magrinelli, H. Houlden, J. Aasly, A. Di Fonzo, A. Brice, S. Lesage, J. Corvol (Paris, France)

A Novel Genome Editing Strategy for Permanent and Precise Downregulation of α-Synuclein in Parkinson’s Disease

B. Manohar, R. Wilson (Berkeley, USA)

A Rare Case of PLA2G6 Gene Related Early-Onset Dystonia-Parkinsonism; What Not to Miss Clinically and Radiologically

Y. Degirmenci (Istanbul, Turkey)

Admixture Mapping of the VA Million Veteran Program Cohort Implicates Novel Genetic Risk Loci for PD Driven by African and Native American Ancestry

O. Lorenzo-Betancor, T. Leal, V. Borda, T. Thornton, T. O'Connor, I. Mata, C. Zabetian (Seattle, USA)

Adult-Onset Incomplete Kufor-Rakeb Syndrome Presenting with Parkinsonism: A Case Report

L. Malfer, F. Onorati, E. Santoro, R. Savica (Rochester, USA)

Age-Related Hearing Loss in Idiopathic Parkinson’s Disease and APOE E4 Carriers

M. Kmiecik, C. Weldon, W. Xu, A. Guan, M. Mcintyre, R. Schneider, A. Auton, S. Aslibekyan (Palo Alto, USA)

Analysis of Genetic Variants Associated with Parkinson’s Disease and Depression

D. Delgado-Gutiérrez, E. Gaspar-Martínez, J. Esquivias-Farias, I. Espinosa-Méndez, E. Fernández-Toledo, A. Medina-Rivera, P. Reyes-Pérez (Querétaro, Mexico)

Analyzing the classification of 767 GBA1 variants to guide GBA1 PD risk prediction

T. Böttcher, M. Radefeldt, C. Beetz, S. Schröder, S. Fischer, S. Oppermann, G. Kramp, J. Pinto Basto, P. Bauer (Rostock, Germany)

Assessing The Role Of Afg3l2 Pathogenic Variants In Parkinson’s Disease

V. Quintana-Peña, I. Keller Sarmiento, B. Bustos, L. Lange, K. Lohmann, R. Alcalay, M. Marti, N. Okubadejo, S. Lim, T. Foroud, R. Kaiyrzhanov, E. Valente, R. Krüger, H. Morris, B. Jeon, C. Klein, J. Trinh, N. Mencacci (Chicago, USA)

Association between Smoking and LRRK2 Variants on Parkinson’s Disease Risk

JDJ. Wang, LL. Chan, E. Ng, KM. Prakash, L. Tan, EK. Tan (Singapore, Singapore)

Association of DAGLB Variants with Early-Onset Parkinson’s Disease Across Populations

Y. Mecheri, W. Kamel, E. Eltaraifee, A. Olusanya, N. Kuznetsov, GP2. Genetic Program, T. Perinan (Constantine, Algeria)

Association of the GCH1 p.Ser80Asn variant with Parkinson’s disease in East Asian populations

YW. Tay, AL. Lee, JP. Schee, CH. Lin, EK. Tan, JH. Shin, PS. Chen, E. Ng, HJ. Kim, BS. Jeon, I. Sarmiento, M. Periñan, L. Lange, P. Heutink, K. Lohmann, C. Klein, N. Mencacci, SY. Lim, A. Ahmad Annuar, AH. Tan (Kuala Lumpur, Malaysia)

Augmenting PD GENEration Genotyping with Continuous Digital Monitoring for Parkinson’s Disease

A. Hare, J. Beck, C. Blauwendraat, K. Galvelis, R. Gilron (New York, USA)

Bridging Genetics and Precision Medicine in Parkinson’s Disease through GP2: Translating Genetic Risk into Trial-Eligible GBA1 and LRRK2 Cohorts

L. Lange, K. Atterling Brolin, E. Navarro-Jones, M. Tan, S. Meyer, D. Vitale, A. Singleton, C. Blauwendraat, M. Nalls, A. Noyce, H. Morris (Bethesda, USA)

Bridging the Genomic Gap: Ancestry-Aware Polygenic Risk and Variant Discovery in African Parkinson’s Disease Cohorts

B. Adebisi (Osogbo, Nigeria)

Characterisation of early onset Parkinson’s disease in UK cohorts

E. Lam, J. Frost, M. Fenn, S. Jasaityte, N. Kuznetsov, L. Lange, D. Vitale, D. Grosset, N. Williams, R. Real, H. Morris (London, United Kingdom)

CHCHD2 Exonic Deletion in a Chilean Parkinson’s Disease Patient: First Latin American Report

E. Fernandez-Toledo, M. Valenzuela, P. Saffie-Awad (Santiago, Chile)

Clinical and Genetic Profile of the ACTIVATE Population: A Phase 2 Trial of BIA 28-6156 in GBA-PD

JJF. Ferreira, RC. Costa, RBM. Bouça-Machado, FRP. Pereira, GC. Cordeiro, TF. Fonseca, MF. Fonseca, DR. Ramos, AG. Guimarães, JH. Holenz (Lisboa, Portugal)

Clinical and Kinematic Assessment of Parkinsonian Features in Young Adults with 22q11.2 Deletion Syndrome

L. Angelini, A. Mazzeo, E. Cerulli Irelli, A. de Core, D. Birreci, AS. Grandolfo, MS. Borioni, S. Aloisio, M. de Riggi, F. Pulvirenti, C. Di Bonaventura, M. Bologna (Rome, Italy)

Clinical Profile and Progression of Parkinson’s Disease in Nigerians with the GBA1 African Ancestry-specific Risk Variant

O. Ojo, N. Okubadejo, NPD. Research Network, GP2. Genetics Program (Lagos, Nigeria)

Clinical-Genealogical Analysis of Parkinson’s Disease

M. Ibodullaeva, R. Matmurodov, KH. Daminova (Tashkent, Uzbekistan)

Clinico-radiological Phenotype of a Unique Family with Mutations in PRKN Over Three Decades

M. Li, W. Liu, R. Mackinnon, C. Sue (Randwick, Australia)

Complex FGF14 Repeat Expansion in Early-Onset Parkinson’s Disease

S. Song, Y. Yang, W. Wang, L. Liu (Jinan, China)

Cross-Family Analysis of Rare Deleterious Variants Segregating in Families with Parkinson’s Disease

C. Gabbert, T. Kleinz, B. Bustos, C. Blauwendraat, SY. Lim, AH. Tan, A. Ahmad-Annuar, YW. Tay, B. Tserensodnom, A. Zimprich, CH. Lin, RRM. Wu, EM. Valente, M. Avenali, SU. Rehman, ZH. Fang, P. Heutink, C. Klein, N. Mencacci, J. Trinh (Chicago, USA)

Cross-trait and Multi-polytranscriptomic Score Prediction of Parkinson’s Disease

L. Gilchrist, O. Pain, S. Calhas, GP2. Genetics Program, A. Noyce, K. Brolin, T. Periñan, P. Proitsi (London, United Kingdom)

Detection of heterozygous ATP7B variants in Hawaii’s Parkinson’s Disease cohort: A case series of six patients

M. Faouzi, K. Thai, R. Shuman, E. Krening, F. Gao, PF. Pdgeneration Study, M. Bruno (New York, USA)

Differential Effect of MAO-B Inhibitors in GBA1 Carriers with Parkinson’s Disease Women vs Men

H. Saragani, R. Henner, M. Cohen, S. Vilk, A. Zimran, I. Harari, R. Eichel, G. Yahalom, M. Cohen (Jerusalem, Israel)

Differential expression of nucleotide excision repair genes in Parkinson’s disease

PBR. Bermúdez Ramírez, SMS. Salas Pacheco, FCJ. Castellanos Juárez, JSP. Salas Pacheco, ASL. Salas Leal, ASC. Sandoval Carrillo (Durango, Mexico)

Discordant Siblings Reveal Determinants of Clinical Penetrance in GBA-Associated Parkinson’s Disease

T. Filidei, SP. Caminiti, R. Malito, P. Mitrotti, R. Calabrese, R. Stiuso, L. Bandirali, L. Gallo, M. Costanzo, P. Di Martino, M. Picascia, A. Pichiecchio, G. Fabbrini, EM. Valente, M. Avenali (Pavia, Italy)

Disease-specific Polygenic Risk Scores and Development of Incident Parkinson’s Disease in a Large Cohort of Healthy Older Adults.

A. Kuri, S. Waters, J. Bestwick, S. Meyer, R. Benabderrazik, A. Shahid, H. Chohan, E. de Pablo-Fenández, C. Simonet, L. Pérez-Carbonell, A. Lees, G. Giovannoni, A. Schrag, A. Noyce (London, United Kingdom)

DJ-1 (PARK7) Heterozygous Mutation and Early-Onset Parkinson’s Disease: A Chilean Case Report and Literature Review

K. Guzmán, M. Sanchez, D. Avila (Santiago de Chile, Chile)

Dropped Head Syndrome From Combined MT‑TE and MT‑ND1 Mitochondrial Variants

J. Chen, W. Tse (New York, USA)

Early-Onset and Familial Parkinson’s Disease in Kyrgyzstan: A PD Cohort Subset for Family-Based Genetic Studies

S. Kyialbekova, E. Zhunusova, C. Shambetova (Bishkek, Kyrgyzstan)

Early-Onset Parkinson Disease in 22q11.2 Deletion Syndrome:Diagnostic Challenges in a Patient With Schizophrenia.A Case Report

L. Salinas-Yañez, J. Altamirano, D. Avecilla-Bonilla, K. Salinas-Barboza (CDMX, Mexico)

Early-Onset Parkinson’s Disease Associated with a Recurrent 16p11.2 Microdeletion Involving PRRT2

N. Jin, X. Zheng, W. Luo (Hangzhou, China)

Elucidating the demographic distributions and implications of GBA1 gene variants in Parkinson’s Disease.

F. Fraser, M. Toffoli, G. Pittwood, A. Anderson, J. Stepniak, A. Schapira (London, United Kingdom)

Evaluating Gene-Environment Interactions between Head Injury and Parkinson’s Disease Risk Variants.

A. Kuri, S. Waters, L. Jones, N. Del Rey, L. Screven, H. Iwaki, M. Nalls, A. Noyce (London, United Kingdom)

Evaluating the GBA1 Intronic rs3115534-G PD Risk Variant in the PD GENEration Cohort

A. Dilliott, K. Ghosh Galvelis, N. Bothwick, R. Deleon, M. Dini, M. Thom, D. Anunciacion, E. Trinh, H. Gao, C. Blauwendraat, A. Singleton, J. Beck, R. Alcalay, P. Pdgeneration Study (Miami, USA)

Evaluation of Polygenic Risk Scores Derived from an Updated Cross-European GWAS for Parkinson’s Disease Prediction in European and Ashkenazi Jewish Populations

B. Pizarro-Galleguillos, L. Faria-Costa, M. Isayan, A. Hernández-Medrano, M. Makarious (Belo Horizonte, Brazil)

Expanded Parkinson’s Disease GWAS in African Ancestry Populations Identifies Novel Risk Loci and Precision Medicine Targets

N. Okubadejo, O. Ojo, H. Leonard, C. Blauwendraat, A. Singleton, M. Makarious, GP2. Genetics Program (Lagos, Nigeria)

Expanding Parkinson’s Disease Genomics in East Africa

R. Mohammad, E. Nyambane, H. Houlden, J. Hooker, D. Sokhi, P. Adebayo, M. Dekker (London, United Kingdom)

Expanding the Clinical Spectrum of 22q11.2 Duplication Syndrome: a 5-year Follow-up of Two Siblings with Young-onset Parkinson’s Disease

A. Milovidov, U. Krikmann (Tartu, Estonia)

Exploring Genetic Contributions to Disease Progression on Hoehn and Yahr Scales in Parkinson’s Disease

L. Jones, N. Kuznetsov, R. Real, E. Navarro-Jones, B. Chase, K. Markopoulou, R. Albin, L. Marsili, C. Lin, L. Pilstrøm,, C. Klein, T. Gasser, T. Anderson, D. Standaert, D. Grosset, M. Hu, B. Warrenburg, W. Berg, H. Morris, H. Iwaki (London, United Kingdom)

Exploring the Causal Role of Mitochondria-related Genes in Parkinson’s Disease through Multi-Omics Mendelian Randomization

Y. Zhang, M. Niu (Shanghai, China)

Exploring the Genetic Architecture of Parkinson’s Disease in North Africa

S. Hrir, H. Nehdi, T. Lüth, C. Gabbert, A. Fienemann, S. Schaake, T. Kleinz, Y. Kanana, F. Nabli, R. Zouari, D. Ben Mohamed, A. Rachdi, Z. Saied, R. Amouri, M. Farrer, F. Hentati, C. Klein, S. Ben Sassi, J. Trinh, GP2. Genetics Program (Lübeck, Germany)

Factors Influencing Participation in Genetic Testing in Parkinson’s Disease Genetic Cohort in Thailand: Patients and Neurologists Perspective

R. Seeluangsawat, K. Horaruengdecha, J. Sringean, R. Bhidayasiri, P. Panyakaew (Bangkok, Thailand)

Fine-Mapping Genetic Risk and Age at Onset Loci in Parkinson’s Disease

S. Jasaitytė, L. Gilchrist, GP2. Genetics Program, A. Noyce, P. Proitsi, K. Brolin, MT. Periñan (London, United Kingdom)

Genetic analysis of Mongolian patients with Parkinson’s Disease

B. Tserensodnom, KH. Tulgaa (Ulaanbaatar, Mongolia)

Genetic analysis of the X chromosome and Parkinson’s disease

N. Kuznetsov, M. Makarious, K. Levine, D. Vitale, C. Blauwendraat, A. Singleton, H. Leonard (Bethesda, USA)

Genetic determinants of cognitive performance in Parkinson’s disease: impact of distal regulatory variation at the SNCA locus in the gp2 cohort

D. Náfate Wences, A. Cervantes Arriaga, M. Rodríguez Violante, MT. Periñán Tocino, GP2. Genetics Program (Mexico City, Mexico)

Genetic Modifiers of Age at Onset for Parkinson’s Disease in European Populations

H. Leonard, L. Lange, M. Makarious, A. Singleton, C. Blauwendraat (Wasington, USA)

Genetic Rare Variation in Early-Onset Neurodegenerative Movement Disorders: A Clinicopathologic Study.

T. Du Toit, L. Wu, O. Serrano, N. Kuznetsov, S. Love, A. King, F. Roncaroli, L. Parkkinen, C. Morris, C. Smith, G. Serrano, T. Beach, S. Gentleman, T. Warner, Z. Jaunmuktane, J. Carr, R. Real, H. Morris (London, United Kingdom)

Genetic Variation in KCNJ6 Gene Increases Risk of Impulse Disorders in Parkinson’s Disease: A Two-Cohort Study

S. García-Díaz, J. Martín-Rodríguez, L. Muñoz-Delgado, R. Díaz-Belloso, S. Jesús, MT. Periñán, M. Martín-Bórnez, AM. Castellano-Guerrero, E. Ojeda-Lepe, D. Macías-García, A. Adarmes-Gómez, D. Buiza-Rueda, M. Bonilla-Toribio, E. Iglesias-Camacho, M. San-Eufrasio, C. Pérez-Calvo, A. Luque-Ambrosiani, F. Carrillo-García, P. Gómez-Garre, P. Mir (Sevilla, Spain)

Genome-wide Discovery of GBA1 Modifiers in Parkinsons Disease Carriers across Populations from the Global Parkinsons Genetics Program

M. Makarious, L. Lange, Z. Fang, A. Singleton, C. Blauwendraat, H. Leonard (Washington, USA)

Genome-wide Discovery of Genetic Modifiers of LRRK2 risk in Parkinson’s Disease Carriers across European Populations

H. Leonard, L. Lange, M. Makarious, Z. Fang, C. Blauwendraat, A. Singleton (Wasington, USA)

GLP1R Expression and Parkinson’s Disease and Related Disorders in GLP-1RA–Treated Type 2 Diabetes

KA. Woo, Y. Jang, P. Park, HJ. Kim (Seoul, Republic of Korea)

Gut Microbiome Metagenomics in Parkinson’s Disease Stratified by the Asian-Prevalent LRRK2 Variants p.G2385R and p.R1628P

TS. Toh, JW. Hor, CH. Lin, J. Tee, Z. Pan, AK. Ng, V. Balakrishnan, AN. Khairul Anuar, LC. Lit, CW. Chong, SY. Lim, AH. Tan (Taipei, Taiwan)

Handwriting in PRKN-PD: A Study of Movement Control

A. Gallagher, C. Fearon, T. Lynch (Dublin, Ireland)

Harmonized Analysis of Parkinson’s Disease-Associated Variants in the AfrAbia PD Genomic Consortium Cohort

WMY. Mohamed (Kuantan, Malaysia)

Higher Dopaminergic Sensitivity Underlies Dyskinesia Occurrence in Indigenous Sabahan PRKN Parkinson’s Disease

JCE. Ooi, YK. Chia, YW. Tay, TZ. Toh, A. Ahmad-Annuar, S-Y. Lim, AH. Tan (Kota Kinabalu, Malaysia)

How large must a Parkinson’s disease trial be to detect pharmacogenomic interactions? Power benchmarks derived from the Exenatide PD3 clinical trial

R. Gurney, C. Girges, N. Vijiaratnam, C. Carroll, M. Hu, G. Duncan, M. Silverdale, T. Foltynie (London, United Kingdom)

Identification of DAGLB Variants in Chinese Patients With Early-Onset Parkinson’s Disease

W. Ren, J. Huang, Y. Guan, W. Zhao, Y. Guo, R. Hua, H. Liu (Changsha, China)

Integrative Analysis of GBA1 Mutations and GCase Deficiency in Parkinson’s Disease using Long Read Nanopore Sequencing

A. Shaikh, S. Prakash, R. Valmiki (Vellore, India)

Interplay of sex and GBA1 and LRRK2 genotype in Parkinson disease progression

J. Park, M. Yang, N. Masood, R. Ortega, D. Raymond, A. Wise, B. Green, K. Leaver, V. Katsnelson, V. Shanker, M. Swan, M. Pullman, A. Domingo, L. Ozelius, S. Bressman, C. Wang, R. Saunders-Pullman (New York, USA)

Intersectin-1 (ITSN1) Loss-of-Function Variants in Parkinson’s Disease: Clinical Phenotypes and Neuropathological Insights

J. Frost, O. Serrano Asensio, J. Ooi, YK. Chia, S. Lim, Y. Tay, C. Lin, A. Robinson, C. Kobylecki, A. Tan, K. Kurian, C. Smith, D. Grosset, L. Parkkinen, Z. Jaunmuktane, T. Warner, C. Blauwendraat, R. Real, H. Morris, GP2. Consortium (London, United Kingdom)

Intra-familial phenotypic variability in a novel Autosomal dominant GCH1 variant

W. Kamel, D. Al Mehatab, M. Mohamed Ibrahim, L. Bastaki (Beni-Suef, Egypt)

Investigating the Genetic Effect of GALC in Parkinson’s Disease

M. Ghamgosar Shahkhali, T. Durcan, Z. Gan-Or (Montreal, Canada)

Investigating the Link Between Alzheimer’s Disease Genetic Risk Variants and Parkinson’s Disease Cognitive Impairment: An Exploration of Genetic Overlap

A. Zirra, S. Jasaityte, P. Dimartino, A. Deoliveira Franco, R. Torricelli, J. Kenny, I. Nakashidze, M. Mshvenieridze, S. Sopromadze, V. van Midden, L. Gilchrist, P. Proitsi, A. Noyce, M. Perinan (London, United Kingdom)

Investigating the role of ATP7B heterozygous variants in Parkinson’s Disease

P. Mitrotti, M. Avenali, P. Dimartino, R. Minardi, G. Pisano, I. Palmieri, A. Fiorentino, L. Malfer, M. Khani, P. Reyes, G. Cossu, V. Carelli, EM. Valente (Pavia, Italy)

Investigation of the Mendelian contribution of parkinsonism associated genes to Parkinson’s disease

G. Cogan, K. Rousvoal, C. Tesson, L. Arnaud, A. Méneret, G. Mangone, S. Sambin, G. Kodjovi, A. Lanore, E. Leguern, J. Corvol, S. Lesage, A. Brice (Paris, France)

ITSN1 Loss-of-Function variants and Parkinson’s disease risk in a Chinese cohort

C. Li, J. Lin, Q. Jiang, J. Huang, S. Wang, X. Zheng, H. Shang (chengdu, China)

Kufor-Rakeb Syndrome With a Novel Splice-Site Variant in the ATP13A2 Gene

L. Zaripova, M. Sadekova, E. Nuzhnyi, N. Abramycheva, E. Fedotova, S. Illarioshkin (Moscow, Russian Federation)

Lack of Association Between Polygenic Risk Scores for Parkinson’s Disease and Age at Onset, Freezing of Gait, or Psychosis

R. Shisgal, T. Davidy, A. Saar, S. Anis, T. Fay-Karmon, A. Sominski, M. Zhang, Z. Gan-Or, L. Grinbaum, S. Hassin-Baer (Ramat Gan, Israel)

Limited Evidence for TPBG Variants in Parkinson’s Disease Risk Across Global Ancestries

R. Laban, R-A. Steopoaie, C. Herghelegiu, N. Ioana, I. Salazar, A. López Lobato, B. Popescu, A. Noyce, M. Periñan, P. Reyes, A. Zirra (London, United Kingdom)

LRRK2 in Focus: A Global Browser Linking Genetic Diversity to Functional Effects

S. Grant, V. van Midden, E. Fernandez, M. Cham, E. Sammler, D. Alessi, H. Morris, C. Blauwendraat, A. Singleton, L. Lange (Bethesda MD, USA)

LRRK2 Mutation Spectrum and Association Study in a Multi-ethnic Cohort of Malaysian Parkinson’s Disease Patients

K. Lim, J. Lim, M. Periñan, Y. Tay, T. Toh, L. Lit, A. Khairul Anuar, H. Ding, K. Ibrahim, A. Mawardi, Y. Chia, J. Ooi, T. Lim, J. Schee, Y. Beh, L. Screven, S. Bandres-Ciga, S. Lim, A. Tan, A. Ahmad-Annuar (London, United Kingdom)

Lysosomal polygenic risk score in Parkinson disease across populations.

W. Sun, K. Brockmann, C. Schulte, T. Gasser, M. Tan (Tübingen, Germany)

MDSGene literature update on autosomal recessive Parkinson’s Disease

T. Kleinz, M. Thomsen, S. Schaake, H. Madoev, M. Doquenia, L. Lange, J. Junker, K. Lohmann, C. Klein (Lübeck, Germany)

Metabolic Brain Pattern and Longitudinal Progression in GBA-Associated Parkinson’s Disease Revealed by 18F-FDG PET/CT

PH. Li, J. Wang, ZY. Qi, XN. Liang, YX. Zhang, FT. Liu, JJ. Wu, J. Wang, CT. Zuo, YM. Sun (Shanghai, China)

Monogenic Parkinson’s Disease Australia (MonoPDAus) Project Update

SF. Siow, V. Flores-Ocampo, K. Weiss, WY. Yau, S. Koks, G. Mellick, H. Morales-Briceno, S. Tisch, C. Wools, J. O'Sullivan, T. Kimber, R. Wilcox, K. Wu, D. Schofield, A. Willis, C. Klein, C. Sue, MA. Young, M. Renteria, K. Kumar (Darlinghurst, Australia)

Motor Fluctuations and Dyskinesias in LRRK2-Associated Parkinson’s Disease

A. Agrebaoui, R. Zouari, A. Mousli, F. Nabli, D. Ben Mohamed, A. Rachdi, MZ. Saied, S. Ben Sassi (Tunis, Tunisia)

Multi-ancestry analysis of POLG variants in Parkinson’s disease

YW. Tay, I. Elsayed, D. Yeow, M. James, S. Rowe, PJ. Kong, L. Screven, H. Chen, A. Dilliott, R. Alcalay, ZH. Fang, AH. Tan, C. Sue, L. Lange, T. Perinan (Kuala Lumpur, Malaysia)

Multi-Ancestry Analysis of Repeat Expansions in Parkinson’s Disease

L. Lange, C. Cerquera-Cleves, A. Tan, S. Lim, N. Okubadejo, C. Lin, P. Chen, J. Shin, A. Ahmad-Annuar, C. Klein, H. Leonard, N. Mencacci, M. Nalls, H. Morris, K. Lohmann, C. Blauwendraat, P. Heutink, Z. Fang (Luebeck, Germany)

Multi-omic, Multi-polygenic Score Prediction of Parkinson’s disease

L. Gilchrist, S. Calhas, S. Jasaityte, O. Pain, GP2. Genetics Program, A. Noyce, K. Brolin, M. Periñan, P. Proitsi (London, United Kingdom)

Mutation screening of Miro1 and Miro2 in Parkinson’s disease

J. Lin, C. Li, D. Pang, R. Ou, Q. Wei, Y. Xiao, T. Yang, Y. Gao, S. Wang, Q. Jiang, J. Liu, Y. Tan, J. Huang, Y. Ma, W. Song, X. Chen, B. Zhao, J. Yang, Y. Cui, H. Shang (Chengdu, China)

Novel associations of VPS13C with phenotype and conversion of idiopathic REM sleep behavior disorder

D. Ding, Z. Zhou, L. Liu (Shanghai, China)

NPC2 is an Allele-Specific Modifier of GBA1-Associated Parkinson’s Disease Risk

J. Kim, R. de Paula, C. Shaw, J. Shulman (Houston, USA)

Nutritional status, clinical Features and lifestyle of Twins Discordant for Parkinson’s Disease

M. Barichella, A. Natale, E. Cereda, E. Contaldi, L. Magistrelli, C. Bolliri, M. Macchione, F. Invernizzi, D. Calandrella, I. Isaias, G. Pezzoli (Pavia, Italy)

Parkinson’s Disease Genetics: From Monogenic Causes to Polygenic Risk and Clinical Translation

X. Liu, X. Zheng, Y. Wang, Y. Yu, H. Shang, C. Li (chengdu, China)

PPP2R5D Variants in Patients Diagnosed With Parkinson’s Disease. A Large‑Scale Multi‑Cohort Analysis

I. Keller Sarmiento, R. Bovenzi, V. Quintana, G. Cogan, A. Brice, A. Gajos, M. Bozi, L. Lange, G. Benbir Senel, B. Tserensodnom, H. Kim, M. Marti, A. Dilliott, H. Morris, S. Lim, A. Tan, R. Alcalay, J. Trinh, C. Klein, N. Mencacci (Chicago, USA)

Predictors of Clinical Progression Over a Decade in GBA1 versus LRRK2 Non-Manifesting Carriers

M. Stark, I. Schoen, E. Mamikonyan, D. Weintraub (Philadelphia, USA)

Preliminary Genetic Spectrum of Parkinson’s Disease in the Israeli PD GENEration Cohort

N. Omer, R. Cohen, T. Gurevich, M. Kalish, A. Thaler, V. Linveh, P. Ponger, M. Cohen, G. Yahalom, I. Harari, T. Fay-Karmon, T. Davidi, A. Saar, L. Greenbaum, S. Hassin-Baer, L. Caboy, A. Dilliot, M. Thom, M. Dini, R. Alcalay (Tel Aviv, Israel)

Prevalence and neuroimaging presentations of Parkinsonism patients with p.R544C NOTCH3 mutation in Taiwan

JJ. Lin (Chu-Shang Jenn, Nantou, Taiwan)

Prognostic Impact of GBA Variants on Mortality in Parkinson’s Disease: A Systematic Review and Meta-Analysis

N. Chan, A. Raphael, J. Kim, A. Haryanto, T. Khoo (Southport, Australia)

Rare GBA c.1157T>G (p.F386C) Variant in Parkinson’s Disease. Case study.

G. Mussagaliyeva, ZH. Myrzayev, CH. Shashkin, D. Bagautdinov, A. Muratbaikyzy (Almaty, Kazakhstan)

Rare Heterozygous SLC25A12 Variants Are Associated with Parkinson’s Disease

K. Senkevich, T. Kleinz, N. Brüggemann, ZH. Fang, Z. Gan-Or, N. Mencacci, C. Blauwendraat, H. Morris, S. Judd, T. Gasser, K. Brockmann, P. Pastor, C. Beetz, P. Bauer, P. Heutink, K. Seppi, F. Krismer, C. Klein, J. Trinh, A. Zimprich (Montreal, Canada)

Rare Variant Analysis in Parkinson’s Disease Patients Stratified by Polygenic Risk

S. Kanagasingam, A. Balan, Z. Gan-Or, K. Senkevich (Montréal, Canada)

Regulatory architecture of the SNCA locus in Parkinson’s Disease: Characterization of reported functional mQTL variants in GP2

D. Náfate Wences, A. Cervantes Arriaga, M. Rodríguez Violante, MT. Periñan Tocino, GP2. Genetics Program (Mexico City, Mexico)

SAA Positivity Rate Amongst Dual LRRK2-GBA1, GBA1 and LRRK2 Carriers with Parkinson’s Disease

P. Ponger, A. Nair, N. Johnson, C. Caspell-Garcia, D. Lafontant, R. Alcalay, P. Ppmi (Heidelberg, Australia)

Sex-Stratified Multi-Omic Integration Identifies Sexually Dimorphic Molecular Targets in Parkinson’s Disease

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Shared and Sex-Specific Genetic Risk for Parkinson’s Disease Across European Populations

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Smell Testing in The Global Parkinson’s Genetics Program (GP2)

S. Meyer, L. Jones, S. Waters, E. Navarro-Jones, M. Tan, K. Atterling-Brolin, L. Lange, M. Teresa Periñan, J. Trinh, C. Gabbert, A. Noyce, G. Genetics Program (London, United Kingdom)

SMR Combined with Multi Omics to Investigate the Mechanism of Action of the Cell Senescence Associated Gene (CDK2AP1) in Parkinson’s Disease

J. Chen, X. Yang (kunming, China)

SNCA Dysregulation Drives Oxidative Stress and Mitochondrial Dysfunction in Parkinson’s Disease: Evidence from a Punjab Cohort

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The Effect of LRRK2 and GBA1 Mutations on Survival in Early- and Late-onset Parkinson’s Disease

R. Rubin, RN. Alcalay, N. Omer, O. Goldstein, M. Gana Weisz, A. Mirelman, A. Thaler (Tel Aviv, Israel)

The Global Parkinsons Genetics Program: Expanding the Diversity of Neurological Disorder Data – 2026 Update

GP2. Global_parkinsons Genetics_program (Bethesda, USA)

Understanding the Earliest Phases of Parkinson’s disease: An Update on the Prodromal Effort Within the Global Parkinson’s Genetics Program

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Young onset Parkinson’s disease patient who has GBA1 pathogenic variant exhibiting progressive supranuclear palsy phenotype

R. Kim, H. Chang, E. Oh (Daejeon, Republic of Korea)

Young-Onset Parkinson’s Disease with Coexisting GBA1 Mutation and ATXN3 Repeat Expansion: A Double Hit?

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