CHAPERONIC PROPENSITIES OF AFRICAN WALNUT AS A THERAPEUTIC TARGET IN MANGANESE-INDUCED PARKINSON-LIKE NEUROPATHOLOGY IN WISTAR RATS
Objective: Herein, the chaperonic propensities of ethanolic extract of African walnut (WNE) in Manganese-induced Parkinson-like neuropathology in the prefrontal cortex and hippocampus was investigated. Background:…Rapamycin attenuates nigral and hippocampal alpha-synuclein accumulation in AAV-mediated alpha-synuclein overexpression model of Parkinson’s disease
Objective: To examine the possible neurorestorative effects of chronic rapamycin treatment in AAV-mediated alpha-synuclein (a-syn) overexpression model of Parkinson’s disease (PD), designed to induce hippocampal…An Unusual Case of Multiple Systems Atrophy with Long Disease Duration, Severe Gliosis, and Scant Synuclein Pathology
Objective: To describe a pathologically unusual case of Multiple systems atrophy (MSA) with severe widespread gliosis and neuronal loss with scant alpha-synuclein (aSyn) pathology. Background:…Double labeling alpha-synuclein in labial minor salivary glands in Parkinson’s disease and idiopathic RBD patients
Objective: To investigate the presence of α-Syn immunostaining in minor salivary gland biopsies (MSGB) from patients with idiopathic Parkinson's disease (PD), idiopathic Rapid Eye Movement…Mapping regional alpha-synuclein seeding capacity in Multiple System Atrophy
Objective: The objective of our work was to develop a novel high-throughput cell-free assay that allowed us to perform a comprehensive characterization of α-synuclein seeding…Lipid metabolism alterations in the lysosomal membrane promotes chaperone-mediated autophagy dysfunction and alpha-synuclein pathology in Parkinson’s disease associated to GBA
Objective: The objective of this study was to generate and characterize a new in vitro neuronal model of Parkinson's diseases associated to GBA (PD-GBA) that…Natural History of Probable MSA in India: A Prospective Cohort Study
Objective: We aimed to prospectively study the natural history of probable multiple system atrophy (MSA) including autonomic testing, survival analysis; and assess whether serum alpha-synuclein…Biofluid Biomarkers in Prodromal Parkinson’s Disease
Objective: To analyze biomarker signatures in biofluids in prodromal Parkinson’s disease (PD) to identify subjects at-risk to conversion and for progression. Background: Individuals at-risk for…Oligodendroglial-derived exosomes as mediators of α-synuclein pathology in MSA-like models
Objective: The current study focuses in elucidating the contribution of oligodendroglial-derived exosomes in the development and spread of α-Synuclein (αSyn) pathology in Multiple System Atrophy…Neurofilament light chain serum levels in E46K-SNCA mutation carriers
Objective: To demonstrate the usefulness of measuring the concentration of neurofilament light chain (NfL) in blood using Single Molecule Array matrix (SiMoA, Quanterix) as a…
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