Chronic Exercise and Systemic Inflammation in Parkinson’s Disease: Exploring the Role of Exercise Modality
Objective: To investigate the effects of 12 weeks of cardiovascular, resistance, multimodal training, or a waiting list condition on the concentrations of inflammatory blood markers…Therapeutic Efficacy of Human Dental Pulp Stem Cells-Derived Exosome-Encased Phloroglucinol In MPTP-Induced Chronic Parkinsonian Rat model: Potential for Disease Modification
Objective: This study aimed to evaluate the therapeutic efficacy of intranasally administered exosome-encased phloroglucinol (Exo-Phl) in a MPTP rat model of PD. Background: Dopaminergic (DA)…Salivary Biomarkers in Parkinson’s Disease: A Follow-Up Study
Objective: Investigate longitudinal changes in salivary levels of oligomeric and total a-synuclein (a-syn), phosphorylated-tau (p-tau), total tau, MAP-LC3, and TNFa in Parkinson’s Disease (PD) patientsAssess…Gut Dysbiosis Alters Host Metabolism but Does Not Independently Induce Parkinson’s Disease Pathology
Objective: To determine whether gut dysbiosis alone is sufficient to induce Parkinson’s disease (PD) pathology and to investigate its impact on host metabolism. Background: Gut…Alpha-Synuclein Preformed Fibrils Increase the Frequency of CXCR3+ B-cells in Early-stage Parkinson’s Disease Patients
Objective: To investigate the effect of a-Syn Preformed Fibrils (PFF) on CXCR3 expression on B-cells in Parkinson’s Disease (PD) patients at early (E-PD, diagnosed less…Hyperbaric Oxygen Therapy for Parkinson’s disease via modulation of gut microbiota
Objective: To investigate the effect of hyperbaric oxygen therapy (HBOT) on gut microbiota in a preclinical model of PD. Background: Humans have coevolved with complex…Immune cell changes in early Dementia with Lewy Bodies
Objective: To examine if immune cell changes are present in early stages of Dementia with Lewy Bodies (DLB). Background: Evidence for inflammation in synucleinopathies has…Paeoniflorin Combined with Neural Stem Cell Transplantation for Parkinson’s Disease: Synergistic Effects of Cell Therapy and Inflammation Regulation
Objective: To investigate the feasibility and efficacy of paeoniflorin (PF) combined with neural stem cell (NSC) transplantation in treating Parkinson's disease (PD). Background: Parkinson's disease…Baseline brain inflammation is associated with less cognitive progression at 24 months in subjects with de novo Parkinson’s disease
Objective: To examine if brain inflammation measured by 18F-DPA-714 imaging is associated with cognitive change in subjects with early Parkinson’s disease (PD). Background: Evidence for…Effects of Low-Intensity Exercise on Motor and Non-Motor Symptoms in a 6-OHDA-Induced Rat Model of Parkinson’s Disease
Objective: This study investigates the effects of low-intensity treadmill exercise on motor, cognitive, and gastrointestinal (GI) functions, as well as neuroinflammation and gut microbiota composition,…
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