Mechanistic Insights of Tamarindus indica in Acrylonitrile-Induced Neurodegeneration
Objective: The study provides an understanding of the nature of the bioactive compounds of Tamarindus indica fruit pulp and their therapeutic potential using in vitro, in…Unveiling the Molecular Mechanism of Polydatin in Ameliorating Parkinson’s Disease via the DRD2/CRYAB/NF-κB Axis in Astrocytes and Exploring Cell Therapy Strategies
Objective: Define polydatin's therapeutic mechanism targeting astrocyte-mediated neuroinflammation in Parkinson's disease (PD) and assess combinatorial efficacy with dopamine progenitor transplantation. Background: PD progression involves substantia…Association of high-density lipoprotein cholesterol and related inflammatory index with neurodegeneration in drug-naïve dementia with Lewy bodies
Objective: We aimed to clarify the association of serum cholesterol levels and related inflammatory index with the degeneration of nigrostriatal dopaminergic neurons and clinical symptoms…Anti-Parkinsonian effects of Globimetula cupulata leaf extract and its underlying mechanisms in 6-hydroxydopamine-lesioned rat model
Objective: To evaluate the neuroprotective effects of Globimetula cupulata in a rat model of Parkinson Disease (PD) induced by 6-hydroxydopamine (6-OHDA) injection in the striatum,…Spatial Multi-Omics Identifies Early Synaptic Pruning and Context-Specific Dopaminergic Vulnerability in Synucleinopathies
Objective: To investigate the significance of Lewy body pathology (LBP) in relation to midbrain molecular and cellular changes associated with Parkinson's disease (PD). Background: The…Beyond Neurodegeneration: Anti-Recoverin Autoantibodies in Immune-Mediated Parkinsonism
Objective: To report a rare case of autoimmune Parkinsonism associated with anti-recoverin antibodies, highlighting atypical presentation , diagnostic challenges and immunotherapy response. Background: Parkinsonism is…L1CAM and TMEM119 enriched Exosomal markers in Parkinson’s Disease and Progressive Supranuclear Palsy: A Prospective Study
Objective: This study explored longitudinal changes in cellular inflammatory, autophagic mediators in L1CAM and TMEM119-enriched exosomal samples of patients with Parkinson’s disease (PD) and Progressive…Characterising Peripheral Innate Immune Cell Infiltration into the Brain in Parkinson’s Disease
Objective: To characterise the infiltration of peripheral innate immune cells (NK cells, monocytes and neutrophils) into the brain in Parkinson’s disease (PD) and to investigate…Peripheral unspecific inflammatory parameters – not always useful in differential diagnosis of parkinsonian syndromes.
Objective: To determine utility of systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII) in differential diagnosis of Parkinson’s disease (PD), progressive supranuclear palsy-Richardson’s…Neutrophil Extracellular Traps Reveal Novel Inflammatory Signatures in Parkinson’s Disease and Multiple System Atrophy
Objective: This cross-sectional study investigates neutrophil extracellular trap (NET) activation in Parkinson’s disease (PD) and multiple system atrophy (MSA) by quantifying plasma levels of NET-associated…
- « Previous Page
- 1
- 2
- 3
- 4
- 5
- …
- 25
- Next Page »