Challenges in Diagnosing and Managing Multiple System Atrophy in Low-Resource Settings: Insights from Nepal
Objective: This study aims to explore the diagnostic and therapeutic challenges faced in the management of Multiple System Atrophy (MSA) in low-resource settings, focusing on…Low Level of Serum Total Cholesterol Predicts Mortality in Early-stage Multiple System Atrophy: a Prospective-cohort Study
Objective: The study aims to clarify the association between baseline level of serum TC and survival of patients with early MSA. Background: Serum total cholesterol…Balance biomarker for early differentiation of Parkinson’s disease and multiple system atrophy with parkinsonian type
Objective: We propose a random forest model utilizing balance analysis to differentiate early-stage Parkinson’s disease (PD) and multiple system atrophy with parkinsonian type (MSA-P) patients.…Anal Sphincter EMG changes can Progress over Time and can be considered as a Prognostic Marker in MSA
Objective: To assess the usefulness of repeat anal sphincter EMG for prognostication of MSA Background: External anal sphincter (EAS) electromyography (EMG) is an established method…Blood and CSF Biomarkers of Cognitive Impairment in Alpha Synucleinopathies
Objective: The aim was to investigate the role of both well-established and novel protein biomarkers of cognitive impairment in Parkinson’s disease (PD) and multiple system…Altered Tryptophan Metabolism and the Role of the Kynurenine Pathway in Multiple System Atrophy
Objective: To elucidate cerebrospinal fluid (CSF) tryptophan metabolism in multiple system atrophy (MSA), focusing on alterations in the kynurenine pathway and its pathological implications. Background:…Real world application of alpha-synuclein skin biopsy in the diagnosis of synucleinopathies at a tertiary care center
Objective: The goal of this study is to review the real-world application of alpha-synuclein skin biopsy at a tertiary care center. Background: Synucleniopathies including Parkinson’s…Intraepidermal Nerve Fiber Density at Baseline Associates with One-year Clinical Disease Progression in Multiple System Atrophy
Objective: In a longitudinal manner explore possible diagnostic and prognostic properties of determining intraepidermal nerve fiber density (IENFD), by means of skin punch biopsy, in…Development and Validation of a Clinical Scale for Distinguishing Multiple System Atrophy from 4-Repeat Tauopathies
Objective: We aimed to develop a clinical scale that distinguishes between Multiple System Atrophy (MSA) and 4-repeat tauopathies (4RT: CBD, PSP) using a standardized neurological…Role of the Alpha-synuclein Seed Amplification Assay in Parkinson’s Disease Clinical Trials: A Case Report of Multiple System Atrophy Misdiagnosed as Parkinson’s Disease
Objective: Report a patient with Multiple System Atrophy (MSA) misdiagnosed as Parkinson’s disease (PD) and enrolled in a clinical trial for PD treatment with Mesenchymal…
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