Locus coeruleus volume is reduced in Parkinson disease-related orthostatic hypotension.
Objective: To test whether structural pathology of the locus coeruleus (LC) is associated with orthostatic hypotension (OH) in Parkinson disease (PD). Background: OH is an…Leg muscle contractions compensate for declining cardiac baroreflex in PD Patients
Objective: To investigate if impairments in muscle contraction affects blood pressure (BP) regulation in PD. Background: Orthostatic hypotension (OH) contributes to unexpected falls in PD.…A qualitative evaluation of the health-related quality of life impact on informal caregivers to patients with neurogenic orthostatic hypotension
Objective: This study aimed to explore the impact of caring for an individual with neurogenic orthostatic hypotension (nOH) through qualitative interviews with informal caregivers and…Orthostatic hypotension in early onset Parkinson’s disease
Objective: To investigate Orthostatic hypotension (OH) feature in early onset Parkinson's disease (EOPD) , especially delayed OH and acute OH post drug. To explore OH…The Clinical Heterogeneity of Orthostatic Hypotension in PD Patients
Objective: The objects of the research were to investigate the clinical heterogeneity of orthostatic hypotension(OH) in PD Patients, to explore the possible risk factors for…Ampreloxetine (TD-9855), a long-acting, norepinephrine reuptake inhibitor (NRI) for the treatment of neurogenic orthostatic hypotension (nOH) in subjects with synucleinopathies: Phase 3 clinical program
Objective: To confirm: 1) clinical efficacy and safety of once-daily oral ampreloxetine in a 4-week double-blind (DB), placebo-controlled (PC) study (NCT03750552); 2) durability of efficacy…Treatment of Neurogenic Orthostatic Hypotension (nOH) in Multiple System Atrophy (MSA) with a wearable Pneumatic Compression Garment utilising Soft Robotics
Objective: To use a novel Pneumatic Garment device for treatment of nOH in MSA. Background: nOH is present in 66-90% of patients with MSA and…Both Symptomatic and Asymptomatic Orthostatic Hypotension is Associated with Cognitive Decline Over Time in Parkinson’s Disease
Objective: To compare cognitive changes over time between Parkinson's disease (PD) patients with orthostatic hypotension (OH) and without OH, and between those with symptomatic OH…Orthostatic hypotension in Parkinson’s disease
Objective: We aimed to identify whether orthostatic hypotension (OH) is a prodromal marker of Parkinson’s disease (PD) or a symptom of later disease. Background: Many…A Phase 2 Study of the Efficacy, Durability and Safety of Ampreloxetine (TD-9855), a Norepinephrine Reuptake Inhibitor, Given Once-daily to Treat Neurogenic Orthostatic Hypotension (nOH) in Subjects with Synucleinopathies
Objective: To assess the efficacy and durability using validated symptom questionnaire OHQ, and safety of ampreloxetine, given once-daily to treat neurogenic orthostatic hypotension (nOH) in…
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