A Phase 2 Efficacy Study of CX-8998, a Potent and Selective T-Type Calcium (Cav3) Modulator in Parkinson’s disease Tremor (PDT) Patients: Design and Dose-Selection Rationale
Objective: The objective of this study is to access the efficacy of CX-8998 using the MDS-UPDRS Tremor Score (MDS-UPDRS-TS) and a digital biomarker platform, while…The Adaptation of Card Games for Education in Movement Disorders
Objective: The objective of this project was to develop and use adapted interactive card games for education in movement disorders. Background: There is a clear…Abrogation of Rotenone Induced Behavior, Biochemical and Mitochondrial Deficits in Mice by Curcumin and Ginkgo Biloba: New Combinational Therapy Approach for Parkinson’s Disease
Objective: This study was designed with the objective to find out the possible synergistic effect of Curcumin (Cur) and Methanolic extract of Ginkgo biloba (EGB)…Impact of SYN120 (a Dual 5-HT6/5-HT2A antagonist) on psychiatric symptoms in patients with Parkinson’s disease dementia: Results from a Phase 2a Study
Objective: To assess the psychiatric effects of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is a dual antagonist of serotonin (5-HT6 and…Classifying Parkinsonian Gait and Turning in Daily Life with Wearable Technology
Objective: We aim to determine the set of gait and turning measures from wearable technology that best separate mobility during daily life in people with…Effect of Ba Duan Jin Exercise on Non-Motor Symptoms, Motor Symptoms, Gait and Balance in Patients with Mild to Moderate Parkinson’s Disease
Objective: There are many traditional exercises in China such as Taijiquan, Wuqianxi and Ba Duanjin. Studies have shown that Taijiquan can help to improve the…Putative treatment of Parkinson’s Disease using extract of Bacopa monnieri
Objective: Bacopa monnieri is largely treasured as a revitalizing herb used by Ayurvedic medical practitioners for almost 3000 years. The herb has been mentioned in…Safety and Efficacy of Levodopa-Carbidopa Monotherapy in Patients with Advanced Parkinson’s Disease
Objective: Evaluate efficacy/safety of levodopa-carbidopa intestinal gel (LCIG) daytime monotherapy (with/without nighttime oral carbidopa/levodopa) vs polytherapy (LCIG with >1 adjunctive therapy) in advanced Parkinson’s disease…A randomized double-blind placebo-controlled trial of probiotics for constipation in Parkinson’s disease
Objective: To investigate the effects of probiotics on constipation in PD, using a randomized controlled trial (RCT) design Background: Non-motor symptoms (NMS) cause significant disability…An early-onset parkinsonism revealing a Gaucher disease with a heterozygous mutation in GBA gene: A case report
Objective: To report a case of a late-onset Gaucher disease (GD) revealed by an atypical Parkinson disease. Background: GD is an autosomal recessive lysosomal disorder,…
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