Targeted deep sequencing of brain DNA for detection of somatic point mutations in synucleinopathies
Objective: To detect relevant somatic "point mutations" (single nucleotide variants- SNVs) in brain-derived DNA in synucleinopathies. Background: There is increasing recognition that neurons may harbour…Sequencing of single human nigral dopaminergic neurons for somatic copy number variants
Objective: To detect somatic DNA copy number variants (CNVs) in dopaminergic neurons isolated from human substantia nigra, using shallow whole genome sequencing (WGS). Background: Somatic…The trace of substantia nigra hyperechogenicity: a clinical observation
Objective: To present an empirical observation regarding transcranial ultrasound in movement disorders and scalp sebum smear. Background: Transcranial ultrasound (TUS) detects substantia nigra hyperechogenicity (SN+) in…Transcranial ultrasound in atypical parkinsonism: how reliable is it in real clinical practice? A multi-centre comprehensive study
Objective: To assess real clinical practice usefulness of transcranial ultrasound in atypical parkinsonism differential diagnosis, and to perform a critical analysis of previous literature in…Substantia Nigra Hyperechogenicity in Parkinson’s Disease and Essential Tremor and its Association with Premotor Symptoms of Parkinson’s Disease
Objective: To compare the frequency of Substantia Nigra hyperechogenicity (SN+) in patients with essential tremor (ET) and Parkinson’s disease (PD), to determine the frequency of…Evaluation of nigral neuronal apoptosis during postnatal development and adulthood of mice strains with differential sensitivity to MPTP
Objective: Compare nigral neurons in C57BL/6J, CD-1 and their F1 crossbreds with respect to developmental apoptosis in the nigra during postnatal and to assess MPTP-induced…Could curcumin be the preventive key of parkinson’s disease?
Objective: The present study evaluates the possible protective effect of curcumin on rats exposed to aluminum which is a major risk factor of parkinson's disease.…The effects of STN-DBS on the Parkinson’s disease patients with different progressive rates
Objective: The aim of this study is to explore the effects of STN-DBS on the Parkinson's disease patients with different progressive rates Background: Studies indicate…Clinical spectrum of vascular Parkinsonism: A hospital-based study in south India
Objective: to Study the profile of akinetic rigid syndromes with special reference to Vascular Parkinsonism Background: Parkinson disease (PD) is a primary neurodegenerative disease but…Prevalence of Autonomic dysfunction and its correlation with Clinico-imageological features in Parkinson’s Disease
Objective: To study the prevalence of autonomic dysfunction and to correlate with clinico-imageological features and to assess the impact of autonomic dysfunction on quality of…
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