Affordable Aspect of Artificial Intelligence Applied to Tremor’s Analysis Features Extraction Approach based on Archimede’s Spiral Processing
Objective: To use automated image analysis framework for tremor feature extraction from Archimedes spirals and analyse the findings based of the tremor’s type. Background: Defining…Dopaminometer: A Smartphone-Based Application to Predict Striatal Dopaminergic Deficit in Prodromal and Manifest Parkinson’s disease
Objective: To assess the feasibility of a smartphone-based application (“Dopaminometer”) for predicting abnormal vs. normal dopamine transporter (DaT) scans and dopaminergic ratios in individuals with…Diagnostic yield of commercial genetic testing for dystonia in a Canadian movement disorders cohort
Objective: This study aimed to assess the diagnostic yield of commercially available genetic panels in dystonia patients and how test performance varies across dystonia subtypes.…Alpha-Synuclein Aggregates in the Olfactory Epithelium of Subjects with Parkinson Disease, Dementia, COVID-19, and in Aged Controls
Objective: We sought to examine whether neuroepithelial structures of the nasal cavity differ between individuals diagnosed with a Lewy body disorder vs those with COVID19…Novel C-KIT/C-Abl Inhibitor BK40196 Alleviates Neurodegenerative Pathology And Improves Behavioral Performance In A53T Mice
Objective: Here we synthesized a novel c-KIT/c-Abl inhibitor BK40196 and investigated its effects on alpha-synuclein, neuro-inflammation , dopamine and behavior in A53T mice. Background: Inhibition…Quercetin Reduces mtDNA Release in PRKN-Deficient and Oxidatively Stressed SH-SY5Y Cells
Objective: This study investigates the role of Parkin deficiency in mitochondrial dysfunction and its contribution to mitochondrial DNA (mtDNA) release in Parkinson’s disease (PD). We…Using R and Python for Kinematic Analysis in Robotic-Assisted Balance Training: A Review of Methodologies and Outcomes
Objective: To review the methodologies and outcomes of kinematic analysis using R and Python in robotic-assisted balance training, highlighting their role in enhancing rehabilitation strategies.…Clinician Advisory Community: Guiding The Michael J. Fox Foundation’s Mission Through Front-Line Intelligence
Objective: Create a survey-ready community of U.S.-based clinicians to share care-focused inputs that inform The Michael J. Fox Foundation’s (MJFF) research funding and recruitment, policy,…Patient-derived α-synuclein seed amplification as a tool for evaluating small molecule aggregation inhibitors for Parkinson’s disease and Lewy Body Dementia therapeutics
Objective: To validate on-target engagement of disease-relevant ⍺-synuclein (a-syn) aggregates by WTX-607, WaveBreak’s small-molecule clinical candidate for Parkinson’s disease (PD) and Lewy body dementia (LBD),…Assessing Physiotherapy’s Role in Parkinson’s Disease Functionality in India: A Case Report
Objective: To find out the Assessing Physiotherapy's Role in Parkinson’s Disease Functionality in India: A Case Report Background: This case report explores the impact of…
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