Remote recruitment of hyposmic participants identifies biomarkers related to neuronal alpha-synuclein disease
Objective: To evaluate the proportion of people with dopaminergic deficit and positive alpha-synuclein seed amplification assay (aSyn SAA) among a remotely identified group of hyposmic…Centralizing brain tissue donation for a large multi-site Parkinson’s disease (PD) study
Objective: Brain tissue analysis is an invaluable resource to better understand PD progression, but there is limited access to this resource and swift postmortem collection…Subgroup Analyses of a Phase 3 Randomized Study of Levodopa/Carbidopa Infusion (ND0612) for Parkinson’s Patients
Objective: Evaluate efficacy and safety outcomes for different patient subgroups categorized according to their baseline characteristics from a Phase 3 study of ND0612. Background: Primary…A Pilot Study of Intrajejunal Faecal Microbiota Transplant to Improve Motor Function in Patients with Parkinson’s Disease Treated with Levodopa-carbidopa Intestinal Gel: Preliminary Findings.
Objective: To determine whether faecal microbiota transplant (FMT) improves motor function in patients with Parkinson Disease (PD) treated with levodopa/carbidopa intestinal gel (LCIG). Background: Preliminary…Comparing Ring and Directional Globus Pallidus Stimulation Effects on Parkinson’s Gait
Objective: This study aims to assess the possible benefits of directional stimulation for motor symptoms in Parkinson’s disease (PD) by comparing therapeutic directional versus ring…Clinic vs Self-Referral for a Home-Based Fracture Prevention Trial of Zoledronate vs Placebo in Patients with Neurodegenerative Parkinsonism
Objective: To evaluate recruitment, eligibility and characteristics of clinic referred vs self-referred patients in the ongoing Trial of Parkinson’s and Zoledronate (TOPAZ, NCT03924414) Background: People…The Impact of Deep Brain Stimulation on the Embarrassment and Self-Esteem of Patients with Essential Tremor
Objective: To examine how Deep Brain Stimulation (DBS) influences embarrassment and self-esteem in patients with essential tremor (ET) and assess caregiver impressions. Background: Social embarrassment…Opicapone as First-Line Strategy for the Treatment of Wearing-off in Patients with Parkinson’s Disease
Objective: The Korean and European ADOPTION studies aimed to explore the efficacy of opicapone (OPC) 50 mg versus an additional 100 mg levodopa dose to…The relationship between pain threshold and striatal dopamine function in Parkinson’s Disease
Objective: This study aims to determine the relationship between pain threshold and striatal dopamine function in people with Parkinson's disease. Background: About 40-85% of Parkinson's…Interim results of a mixed method research-in-action study to evaluate and improve patient and public involvement within the EJS ACT-PD initiative
Objective: To improve patient and public involvement and engagement (PPIE) within EJS ACT-PD by evaluating members’ perceptions of PPIE through a mixed methods research-in-action study.…
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