Clinical Characteristics of Sporadic Parkinson’s Disease with Negative CSF Alpha-synuclein Seed Amplification Assay
Objective: Define clinical characteristics of individuals with sporadic Parkinson’s disease (sPD) enrolled in the Parkinson’s Progression Markers Initiative (PPMI) who have a negative CSF alpha-synuclein…Cognitive and Motor Wobbling in Isolated RBD: A Multicentric Study by the International RBD Study Group (IRBDSG)
Objective: To define and characterize clinically fluctuating transition phases from isolated RBD (iRBD) to overt alpha-synucleinopathy. Background: Patients with iRBD often develop motor and non-motor…Reduced plasma levels of small HDL subfractions in advanced Parkinson’s disease
Objective: The present study investigated alterations of circulatory lipoprotein profiles, including cholesterol, triglycerides (TGs), phospholipids (PLs) and apolipoproteins (Apo) in lipoprotein subfractions, in Parkinson's disease…Impact of Over-the-counter Cannabidiol Products on Cognition During the Course of Parkinson’s Disease
Objective: To evaluate the association between Cannabidiol (CBD) usage and cognitive performance, measured by The Montreal Cognitive Assessment (MoCA) in people living with Parkinson's Disease…Individual physiomarkers of levodopa-induced local field potential fluctuations interact with deep brain stimulation in Parkinson’s disease
Objective: We investigated the behavior of LFPs in 57 patients across therapeutic states using a data-driven method to find personalized physiomarkers. Background: The power of…Quantitative Digitography and Home Diaries for PD Motor State Evaluation
Objective: Assess the feasibility of people with Parkinson’s (PwP) performing 30 seconds of repetitive alternating finger presses using Quantitative Digitography (QDG) technology every 30 minutes…Paradoxical Association of Kinetics of α-Synuclein Seed Amplification 24-hrs Assay and Clinico-Pathological Markers of Parkinson’s disease
Objective: To investigate the association between baseline α-synuclein seed amplification assay (SAA) parameters and clinical and biomarker features of Parkinson’s disease (PD) at baseline and…Characterization of DBS-induced Speech Improvements in a German PD Cohort
Objective: To investigate speech changes induced by subthalamic deep brain stimulation (DBS) in persons with Parkinson’s disease (pwPD). Background: Dysarthria is a common debilitating motor…Blood and CSF Biomarkers of Cognitive Impairment in Alpha Synucleinopathies
Objective: The aim was to investigate the role of both well-established and novel protein biomarkers of cognitive impairment in Parkinson’s disease (PD) and multiple system…Low-frequency pallidum evoked potential dynamics as a prospective biomarker for Parkinson’s disease
Objective: Characterize low-frequency evoked potential (EP) activity induced by deep brain stimulation (DBS) in the internal globus pallidus (GPi) and how the EP dynamics modulate…
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