Advancing the regulatory maturity of digital health technologies with focus on early intervention, Critical Path for Parkinson’s 3DT initiative
Objective: To report the feedback from global regulatory agencies to Critical Path Institute (C-Path) on the use of digital health technologies (DHTs) for Parkinson’s disease…Personality Traits and Neuropsychiatric Assessment in De Novo, Clinically Established Body-First and Brain-First Parkinson’s Disease
Objective: To assess and compare personality profiles and psychiatric symptoms in de-novo clinically-established body-first and brain-first PD. Background: Body-first and brain-first have recently been proposed…Orthostatic Hypotension and Acute Cognitive Dysfunction in Parkinson’s Disease: Insights from fNIRS
Objective: To define cerebral oxygenation changes during positional cognitive testing in Parkinson’s disease (PD), comparing those with orthostatic hypotension (OH+) to those without (OH-). Background:…Caution in the creation of Parkinson’s disease cognitive composites
Objective: To evaluate the structural validity of new cognitive composites in Parkinson’s disease (PCCs). Background: PCCs created from constituent tasks are promising in their single-index…Baseline cerebrospinal levels of p-tau and amyloid beta and striatal dopamine transporter binding predict mild cognitive impairment and dementia diagnosis in Parkinson’s disease
Objective: To assess whether baseline measurements of neuroimaging and biofluid-based biomarkers predict diagnosis of mild cognitive impairment (MCI) and dementia at 5-year follow-up in early…Deep Brain Stimulation Increases Motivation to Obtain Larger Rewards in Parkinson’s Disease
Objective: To assess the effects of deep brain stimulation (DBS) on effort and reward processing for self-benefitting and prosocial behavior in people with Parkinson’s Disease…Modified Delphi consensus approach to develop recommendations for diagnosis, evaluation and management of cognitive disorders in Parkinson’s disease
Objective: We aimed to develop harmonised recommendations for the diagnosis, evaluation and management of cognitive disorders in PD using a modified Delphi process. Background: Differences…Longitudinal Analysis of Cognitive Changes in Parkinson’s Disease Subjects at Risk of Developing Probable REM Sleep Behavior Disorder (RBD)
Objective: To characterize the cognitive profile of Parkinson’s Disease (PD) patients that develop probable REM sleep behavior disorder (pRBD) within 8 years after PD diagnosis…Neuroimaging and CSF Correlates of Minor Hallucinations in Parkinson’s Disease
Objective: To investigate associations between minor hallucinations (MH), cognition, CSF biomarkers, and neuroimaging findings in non-demented patients with idiopathic Parkinson’s disease (PD). Background: MH including…The value of PET imaging in Parkinson’s disease with cognition impairment
Objective: The purpose of this study was to explore the diagnostic value of PET imaging, plasma biomarkers in the diagnosis of cognitive dysfunction in Parkinson's…
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