2025 International Congress » Parkinson's Disease: Genetics

16-years of Evaluations for Prodromal Parkinson Features in an At-Risk Cohort with Gaucher Disease

E. Sidransky, E. Ryan, S. Nishimura, N. Tayebi, G. Lopez (Bethesda, MD, USA)

A Case for Novel Phenotypes Associated with Digenic CHMP2B-LRRK2 Mutations

D. Vijaywargiya, T. Chabrashvili (Liverpool, USA)

A Multi-Transcriptional Risk Score Approach to Parkinson’s Disease Prediction

L. Gilchrist, O. Pain, A. Noyce, K. Brolin, M. Periñán, P. Proitsi (London, United Kingdom)

A Pan-Indian Genome-Wide Association Study of Parkinson’s Disease

A. Kishore, A. Sreelatha, A. Tenghe, R. Borgohain, D. Puthenveedu, R. Rajan, L. Ricardo, P. Pal, R. Mridula, M. Urulangod, R. Yadav, S. Mehta, H. Kumar, P. Agarwal, N. Kumar, P. Kukkle, S. Desai, M. Sharma (Tubingen, Germany)

A unique genetic duality: GAK and SCN4A Mutations in Myasthenic Syndrome and Early-Onset Parkinsonism in a Peruvian woman: A Case Report

W. Trillo Alvarez, A. Carpio Peña, L. Delgado Villanueva, A. Gomez Azcue, H. Paz-Soldan Candia, M. Nieto Rosas, D. Flores Barragan, F. Arismendi Gomez (AREQUIPA, Peru)

Advancing Global Training and Capacity Building in Parkinson’s Genetics through GP2

MT. Periñan, S. Dey, S. Finch, H. Leonard, M. Makarious, K. Atterling Brolin, A. Zirra, K. Step, V. van Midden, YW. Tay, Y. Mecheri, L. Faria-Costa, E. Fernandez-Toledo, V. Flores-Ocampo, C. Shambetova, A. Noyce, S. Bandres-Ciga, GP2. Genetics Program (Sevilla, Spain)

Analysis of LRRK2 Exonic Variants in Parkinson’s Disease in Chinese Population

ZY. Qi, YM. Sun, J. Wang (Shanghai, China)

Analysis showed resemblance in Genetic architecture of rare movement disorders in consanguineous Pashtoon ethnic group

S. Rehman (Bannu, Pakistan)

Applying growth mixture models to elucidate heterogeneous trajectories of cognitive change in Parkinson’s Disease

M. Yang, C. Wang, D. Raymond, A. Wise, K. Leaver, V. Katsnelson, V. Shanker, M. Swan, C. Young, M. Beltre, M. Pullman, B. Green, N. Masood, A. Astefanous, A. Cohen, S. Bressman, R. Saunders-Pullman (New York, USA)

Artificial Intelligence Unveils Genetic Etiologies in Parkinson’s Disease: Cases Clustered by Clinical Features

G. Di Rauso, A. Ghibellini, F. Pirone, G. Franco, F. Arienti, E. Frattini, I. Trezzi, F. Cavallieri, L. Bononi, M. Gabbrielli, F. Valzania, E. Monfrini, A. Di Fonzo (Reggio Emilia, Italy)

Assessing Genome-wide Genetic Risk for Parkinson’s Disease Age at Onset in European Sub-Populations: from the Global Parkinson’s Genetics Program

GP2. Parkinson'S_genetics_program (Bethesda, USA)

Assessing Individual Risk Through Determination of Local Ancestry: Insights from the Global Parkinson’s Genetics Program

M. Makarious, T. Leal, E. Waldo, D. Vitale, M. Koretsky, S. Hong, S. Yeboah, K. Levine, H. Leonard, M. Nalls, I. Mata, GP2. Parkinson'S_genetics_program (gp2) (Maryland, USA)

Assessing the potential association of rs2298383 in ADORA2A as a predictor of Levodopa-Induced Dyskinesia in Latin American Parkinson’s Disease patients

HM. Chaparro-Solano, E. Waldo, T. Peixoto-Leal, AF. Schumacher-Schuh, BL. Santos-Lobato, E. Gatto, G. Arboleda, JL. Orozco-Velez, P. Chana-Cuevas, D. Aguillon, M. Rodriguez-Violante, D. Martinez-Ramirez, M. Cornejo-Olivas, A. Vinuela, G. Alvarado, P. Olguín, S. Alcauter, IF. Mata (Cleveland, USA)

Association Analysis Between Genotypes and Disease Progression in Parkinson’s Disease

ZY. Qi, YM. Sun, J. Wang (Shanghai, China)

Association Between Hyperuricemia, Gout, and the Risk of Parkinson’s Disease: An Updated Systematic Review and Meta-Analysis

F. Qtaishat, J. Yasin, R. Odat, M. Alsufi, A. Abunamoos (Irbid, Jordan)

Association of Mitochondrial DNA Haplogroup and pS65-Ub Levels in Lewy Body Disease

N. Tran, X. Hou, M. Heckman, F. Fiesel, S. Koga, D. Dickson, W. Springer, O. Ross (Jacksonville, USA)

Association of sequence alterations in the promoter region of the RAB7L1 gene with lysosomal hydrolase activity in blood and reduced risk of Parkinson disease

K. Basharova, A. Bezrukova, K. Senkevich, G. Baydakova, I. Miliukhina, A. Timofeeva, E. Zakharova, S. Pchelina, T. Usenko (Gatchina, Russian Federation)

Asymptomatic GBA1 Mutation Carriers Have Increased Cortical Cholinergic Activity

M. Matarazzo, J. Mckenzie, S. Dhaliwal, Q. Miao, N. Vafai, R. Alcalay, V. Bruno, A. Lehman, J. Quinn, D. Raymond, D. Safarpour, J. Sarna, R. Saunders-Pullman, S. Sirrs, CP. Zabetian, V. Sossi, AJ. Stoessl (Vancouver, Canada)

Building Genetic Counseling Capacity in Latin America: The PD GENEration–LARGE-PD Training Framework

V. Caceres, R. de León, M. Inca Martinez, I F. Mata, A. Coral, P. Hodges (Indianapolis, USA)

CAP-003, a CNS-targeted IV-delivered AAV Gene Therapy Developed for Patients with Parkinson’s Disease associated with GBA1 Mutations

K. Mcdowell, R. Ressler, M. Flynn, B. Wheeler, L. Grigoryeva, A. Armendariz, H. Acharya, P. Denis, J. Granados, P. Tchourilov, C. Pedeferri, M. Brandabur, S. Tole, N. Goeden, N. Flytzanis (Thousand Oaks, USA)

Clinical and neuro-imaging predictors of falls in PLA2G6-related Parkinsonism: a retrospective study

C. Chen, Y. Sun, H. Dai, F. Liu, . Jun, X. Liu, J. Wang (Shanghai, China)

Clinical Differences Among Parkinson’s Disease Patients Carrying GBA1 Variants in Colombia: Insights From LARGE-PD Consortium

T. Lopez Gonzalez, S. Poveda, HM. Chaparro Solano, J. Ramchandra, E. Waldo, L. Santiago, T. Leal, M. Inca, O. Bernal-Pacheco, G. Arboleda Bustos, H. Arboleda, C. Cerquera, L. Quintero-Giraldo, C. Moreno-Gonzalez, B. Muñoz-Ospina, JL. Orozco, DA. Pineda, O. Buritica, D. Aguillon, M. Jimenez-Del Rio, C. Velez-Pardo, IF. Mata (Cleveland, USA)

Deep phenotyping of Parkinson‘s disease patients with the RAB32 Ser71Arg pathogenic variant and MDSGene literature review

T. Kleinz, F. Cavallieri, M. Borsche, G. Toschi, F. Valzania, EM. Valente, P. Mitrotti, M. Avenali, S. Zittel, R. Born, M. Matarazzo, C. Shambetova, N. Griebner, L. Santinelli, M. Brand, C. Gabbert, A. Westenberger, J. Trinh, M. Radefeldt, C. Beetz, P. Bauer, N. Brüggemann, C. Klein (Reggio Emilia, Italy)

Description Genotype/phenotype of patients with Parkinson’s disease. Report of an Argentinean cohort included in the LARGE PD Consortium.

M. Espindola, N. Gonzalez Rojas, G. da Prat, M. Cesarini, J. Etcheverry, I. Mata, C. Perandones, E. Gatto (Cleveland, USA)

Disclosing CLIA certified genetic results within the LARGE-PD Cohort in Peru: Preliminary results of the PD GENEration study

A. Manrique-Palomino, F. Requejo-Navarro, M. Inca-Martinez, A. Rivera Valdivia, E. Sarapura-Castro, V. Marca, C. Armas, M. Illanes- Manrique, J. Rios-Pinto, K. Mejia-Rojas, A. Medina-Collque, I. Cornejo-Herrera, E. Ochoa-Valle, P. D. Hodges, R. de León, I. F. Mata, M. Cornejo-Olivas (Lima, Peru)

Distribution of Genomic Ancestries and Genetic Variation Among Individuals Enrolled in the PD GENEration Study

A. Dilliott, K. Ghosh Galvelis, N. Bothwick, L. Caboy, M. Caulfield, R. de Leon, M. Dini, I. Khaderi, S. Rao, A. Yake, A. Coral Zambrano, J. Solle, C. Blauwendraat, A. Singleton, J. Beck, R. Alcalay (Miami, USA)

Does COMT Play a Role in Parkinson’s Disease Susceptibility Across Diverse Ancestral Populations?

M. Martin-Bórnez, N. Shar, M. Nour, D. Murphy, I. Elsayed, M. Shri, F. Nwaokorie, A. Olusanya, N. Kuznetsov, S. Bandres-Ciga, A. Noyce, H. Iwaki, L. Jones, P. Gómez-Garre, P. Mir, MT. Periñan (Sevilla, Spain)

Early-onset levodopa-responsive parkinsonism with cognitive impairment and head-bobbing dyskinesias associated with SYNJ1 and GBA variants of unknown significance

S. Rodrigo, M. Rosenbaum, J. Fleisher (Chicago, USA)

European-Derived Parkinson’s Disease Polygenic Risk Score Model Is Associated With PD Status, UPDRS Score But Not Age At Onset Or Cognitive Impairment In An Egyptian PD Dataset

S. El-Shafie, A. Nagano, I. Elsayed, E. Khedr, M. William, A. El-Hosseiny, A. Shalash, G. Fawi, M. Yousef, S. El-Jaafary, H. Lee, A. Jama, M. Koraym, Y. Salah, A. Atputhavadivel, S. Elfarrash, Y. Elsaid, A. Gabr, N. Shebl, L. Aly, N. Abdelwahhab, T. Belal, N. Elsayed, M. El-Gamal, S. Elgamal, S. Ragab, J. Mekky, H. Houlden, M. Salama, M. Rizig (Cairo, Egypt)

Examining the Gut Microbiome in Parkinson Patients with GBA Mutations

H. Dainton-Howard, A. Keshavarzian, A. Kirby, C. Goetz (Chicago, USA)

Exome-wide Burden Analysis Identifies SYT10 as a Genetic Modifier of GBA-PD in UK Biobank

J. Kim, J. Shulman (Houston, USA)

Familial parkinson disease A comparative study between LRRK2 and PINK 1 mutations

A. Mousli, R. Zouari, Z. Saeid, F. Nabli, A. Rachdi, D. Ben Mohamed, S. Ben Sassi (Tunis, Tunisia)

First in Class ASO Targeting A53T Allele: Preclinical Efficacy

S. Smieszek, B. Przychodzen, C. Tyner, C. Polymeropoulos, G. Birznieks, M. Polymeropoulos (Washington, USA)

First Insights into Genetic Findings from the Mexican Parkinson’s Research Network (MEX-PD): The Case of MTHFR

P. Reyes-Pérez, A. Lazaro-Figueroa, I. Estrada-Bellmann, Y. Matuk-Pérez, C. Guerra-Galicia, K. Salinas-Barboza, E. Morelos Figaredo, N. Gandarilla-Martínez, V. Flores-Ocampo, E. Waldo, A. Zayas-Del Moral, I. Espinosa-Méndez, M. Inca-Martinez, U. Caballero-Sánchez, T. P. Leal, I. Mata, E. Gaspar-Martínez, M. Rentería, S. Alcauter-Solorzano, A. Ruiz-Contreras, A. Medina-Rivera (Queretaro, Mexico)

Gene Polymorphisms of Parkinson’s Disease risk locus and idiopathic REM Sleep Behavior Disorder

Y. Li, J. Liu, M. Zhong (shanghai, China)

Gene-Caffeine Interaction in Parkinson’s Disease: A Case-Control Study of Alpha-synuclein SNPs

BG. Yan, E. Ng, Y. Zhao, EK. Tan (Singapore, Singapore)

Genetic Analysis of Parkinson’s Disease in Crete

I. Boura, S. Sait, N. Marinakis, A. Kumar, P. Reho, I. Vatsellas, T. Loupis, P. Makrythanasis, P. Mitsias, G. Xiromerisiou, S. Scholz, C. Spanaki (Heraklion, Crete, Greece)

Genetic analysis of the X chromosome and Parkinson’s disease: from the Global Parkinson’s Genetics Program

GP2. Parkinson'S_genetics_program (gp2) (Chevy Chase, USA)

Genetic Correlations Between Parkinson’s Disease and Circulating Metabolites

M. Tan, T. Ascencio, S. Rodriguez-Quiroga, J. Largo González, S. Peña Martinez, L. Hernandez Delgado, A. Noyce (San Salvador, El Salvador)

Genetic risk modifiers for GBA1 carriers in Parkinson’s disease: from the Global Parkinson’s Genetics Program

GP2. Parkinson'S_genetics_program (gp2) (Chevy Chase, USA)

Genetic variants detection and prevalence in Hawaii’s diverse PD population

M. Faouzi, K. Thai, R. Shuman, E. Krening, A. Yake, F. Gao, M. Bruno (Hawaii, USA)

Genetics of African Americans – Louisiana, Parkinson’s Disease – (GoAAL-PD)

J. Staisch, S. Breaux, D. Thomas, C. Cevallos, C. Robinson, J. Hines, A. Bonano, L. Davis, J. Henry, N. Crovetto, E. Levenes (New Orleans, USA)

Genome-wide Association Analyses Reveal Susceptibility Variants Linked to Parkinson’s Disease in the South African Population Using Inferred Global and Local Ancestry

K. Step, T. Peixoto Leal, E. Waldo, L. Madula, Y. Swart, C. Hernández, S. Bandres-Ciga, J. Kim, I. Mata, S. Bardien (Cape Town, South Africa)

Genotypic and phenotypic characterization of the population living with Parkinson disease in the northwest region of Argentina

C. Avila, G. Alvarado, L. Rojas-Vazquez, J. Diaz-Rearte, E. Franchello (San Miguel de Tucuman, Argentina)

Hispanic Recruitment to PD GENEration at Columbia University

A. Arroyo, H. Lee, M. Dini, L. Caboy, K. Ghosh Galvelis, R. de Leon, J. Agin-Liebes (New York, USA)

Identifying Differential DNA Methylation Pathways in Parkinson’s Disease and REM Sleep Behavior Disorder

Z. Wu, C. Song, J. Ruiz Tejeda, R. Rajmohan, R. Malhas, M. Mapstone, W. Li, N. Phielipp (Irvine, USA)

Impact of rare lysosomal gene variants on Parkinson’s disease

K. Senkevich, S. Parlar, C. Chantereault, L. Liu, E. Yu, U. Rudakou, J. Ruskey, J. Ahmad, F. Asayesh, D. Spiegelman, C. Waters, O. Monchi, Y. Dauvilliers, N. Dupré, L. Greenbaum, S. Hassin-Baer, I. Miliukhina, A. Timofeeva, A. Emelyanov, S. Pchelina, R. Alcalay, Z. Gan-Or (Montreal, Canada)

Improving Recruitment of Black and African American Participants in Parkinson’s Genetics Research

N. Louie, C. Kelliher, MN. Dean, D. Hall, EA. Shamim, T. Xie, E. Disbrow, A. Rawls, A. Ameri, S. Chandra, E. Foster, V. Hinson, C. Kilbane, S. Norris, L. Shulman, J. Staisch, LM. Chahine (New York, USA)

Inflammatory profile in LRRK2-associated prodromal and clinical PD:a cross-sectional study

CC. Fan, JY. Liu, JH. Ma, XL. Liu, P. Chan, SY. Liu (Beijing, China)

Insights into Ancestral Diversity in Parkinson’s Disease Risk: A Comparative Assessment of Polygenic Risk Scores

S. Grant, P. Saffie-Awad, M. Makarious, I. Elsayed, A. Sanyaolu, P. Wild Crea, A. Schumacher Schuh, K. Levine, D. Vitale, M. Koretsky, J. Kim, T. Leal, M. Periñan, S. Dey, A. Noyce, A. Reyes-Palomares, N. Rodriguez-Losada, J. Foo, W. Mohamed, K. Heilbron, L. Norcliffe-Kaufmann, M. Rizig, N. Okubadejo, M. Nalls, C. Blauwendraat, A. Singleton, H. Leonard, I. Mata, S. Bandres-Ciga (Bethesda, USA)

Insights into Genetic Counseling Recall and Clinical Trial Interest in PD GENEration

S. Rao, M. Murray, L. Caboy, R. de Leon, L. Desnoyers, M. Dini, K. Ghosh Galvelis, J. Beck, R. Alcalay (Miami, USA)

Interplay of GBA1 mutations and sex on determining depressive symptoms in Parkinson’s Disease

M. Avenali, P. Mitrotti, CA. Artusi, R. de Micco, G. Giannini, S. Caminiti, C. Ledda, L. Gallo, C. Galandra, A. Mascia, M. Siciliano, F. Pagliuca, L. Sambati, V. Sant'Elia, G. Vornetti, G. Calandra-Buonaura, L. Lopiano, R. Lodi, A. Tessitore, M. Bozzali, EM. Valente (Turin, Italy)

Interrogating GCase Activity in Human Monocytes Isolated from Parkinson’s Disease Patients Carrying the Asian LRRK2 G2385R and R1628P Variants

TS. Toh, JW. Hor, SY. Lim, LC. Lit, AN. Khairul Anuar, CY. Lew, YW. Tay, JL. Lim, A. Ahmad-Annuar, K. Zeneviciute, D. Alessi, E. Sammler, AH. Tan (Kuala Lumpur, Malaysia)

Investigating the Global Genetic Spectrum of Monogenic Parkinson’s Disease and Parkinsonism

L. Lange, M. Makarious, M. Avenali, S. Bardien, M. Doquenia, C. Galandra, P. Heutink, J. Junker, Y. Kanana, I. Keller Sarmiento, K. Kumar, H. Leonard, K. Levine, SY. Lim, K. Lohmann, N. Mencacci, M. Nalls, AH. Tan, J. Trinh, EM. Valente, C. Blauwendraat, S. Bandres-Ciga, A. Singleton, ZH. Fang, C. Klein (Bethesda, USA)

Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations

F. Akcimen (Bethesda, USA)

Linking Adolescent Brain Development To Parkinson’s Disease Risk Using Machine Learning On Polygenic Risk Scores

L. Liu, R. Zhu, E. Yu, X. Liu, R. Ge, A. Dagher, Z. Gan-Or (Montreal, Canada)

Longitudinal Analysis of Disease Progression in GBA-Associated Early-Onset Parkinson’s Disease

YM. Sun, PH. Li, ZY. Qi, FT. Liu, JJ. Wu, J. Wang (Shanghai, China)

LRRK2 Polymorphisms and Associations with Parkinson’s Disease in Participants of East Asian, Southeast Asian, and European Descent

S. Nguyen, R. Edillor, J. Ruiz-Tejeda, R. Rajmohan, N. Phielipp (Irvine, USA)

Mining Metabolomics GWAS for Key Parkinson’s Disease Variants: A Bioinformatics Approach to Genetic-Metabolic Associations

S. Rodríguez-Quiroga, T. Ascencio, J. Largo Gonzalez, S. Peña Martinez, L. Hernandez Delgado, A. Noyce, M. Tan (Buenos Aires, Argentina)

Monogenic Parkinson’s Disease patients in Central Europe within the CEGEMOD consortium

M. Ostrozovicova, G. Tamas, P. Dusek, M. Grofik, V. Han, P. Holly, R. Jech, P. Klivenyi, N. Kovacs, E. Kurca, A. Lackova, J. Necpal, D. Pinter, E. Ruzicka, T. Serranova, K. Smilowska, I. Straka, T. Svorenova, P. Valkovic, K. Zarubova, H. Houlden, M. Rizig, M. Skorvanek (Kosice, Slovakia)

Mutations of the VPS13A gene in a patient with Early-Onset Parkinson’s Disease: A case report.

H. Pacheco, V. Gómez, C. Sánchez, L. Núñez (Mexico, Mexico)

Non-motor Symptoms, Sleep Disturbances, And Genetic Insights In Young Onset Parkinson’s Disease: A Prospective Descriptive Study

L. Sahoo, V. Choudhary, A. Mishra (Bhubaneswar, India)

Novel Parkinson’s Disease Genetic Risk Factors Within and Across European Populations

GP2. Parkinson'S_genetics_program (Bethesda, USA)

Oculomotor Differences in PARK2 PD: a Study of Structured and Unstructured Eye Movements in an Irish Genetic Cohort

A. Gallagher, C. O'Keeffe, J. Inocentes, M. Bradley, E. Donlon, B. Coe, B. White, R. Walsh, T. Lynch, R. Reilly, D. Munoz, C. Fearon (Dublin, Ireland)

Parkinson’s disease (PD) associated with the E46K mutation in the SNCA gene, twenty years after

B. Tijero Merino, MA. Acera Gil, I. Gabilondo, T. Fernandez Valle, M. Ruiz Lopez, R. Sanchez Pernaute, A. Murueta-Goyena, I. Diez, C. Juanes, R. Del Pino, N. Ayo-Mentxakatorre, JC. Gomez-Esteban (Barakaldo, Spain)

Prevalence and Characteristics of Glucocerebrosidase Genetic Variants in Nepalese Early-onset Parkinson’s Disease Patients

R. Ojha, B. Gajurel, N. Gautam, R. Karn, R. Rajbhandari, S. Shahi, V. Sharma, S. Baidya, A. Bhattarai, A. Niraula, E. Tuladhar, A. Adhikari, Y. Tay, S. Lim, A. Tan (Kathmandu, Nepal)

Prevalence and Local Ancestry of LRRK2 p.Q1111H in Latin American Cohort

E. Waldo, TP. Leal, M. Inca-Martinez, S. Alcauter, G. Arboleda Bustos, C. Avila, V. Borges, P. Chana, M. Cornejo-Olivas, E. Gatto, G. Letro, B. Lobato, D. Martinez-Ramirez, A. Medina, V. Muller, P. Neto, K. Nuytemans, P. Olguin, J. Orozco Velez, V. Raggio, M. Rodriguez-Violante, A. Schuh, G. Torrealba, V. Tumas, C. Velez-Pardo, A. Viñuela, IF. Mata (Cleveland, USA)

Rapid Neurologic Decline after Subthalamic Nucleus Deep Brain Stimulation in Leucine-Rich Repeat Kinase 2 Parkinson’s disease (LRRK2-PD)

T. Haddad, M. Rochman, TW. Liang (Phialdelphia, USA)

Rare Variant Analysis of Sphingolipid-related Genes in Large Chinese Parkinson’ s Disease Cohorts

JB. Liu, YW. Zhao, XM. Guo, Q. Yin, R. Gao, BS. Tang, JF. Guo (Changsha, China)

Rare Variants in RAB GTPases in Parkinson’s Disease

C. Gabbert, AJ. Stoessl, AH. Tan, L. Eade, E. Zhunusova, J. Follett, S. Schaake, BS. Malek, C. Shambetova, K. Andersh, YW. Tay, A. Ahmad-Annuar, Z. Gan-Or, M. Ghamgosar Shahkhali, TS. Toh, GP2. Genetics Program, C. Klein, SY. Lim, D. Alessi, M. Farrer, J. Trinh (Lübeck, Germany)

Rare Variants, Copy Number Variations, and Heritability Estimates in a Pilot Cohort of Egyptians with Parkinson’s Disease

M. Yousef, A. El-Hosseiny, A. Nagano, A. Atputhavadivel, E. Khedr, M. William, A. Shalash, G. Fawy, S. El-Shafie, S. El-Jaafary, M. Koraym, Y. Salah, S. Elfarrash, Y. Elsaid, A. Gabr, N. Shebl, L. Aly, N. Abdelwahhab, T. Belal, N. Elsayed, M. El-Gamal, S. Elgamal, S. Ragab, J. Mekky, M. Salama, M. Rizig (Cairo, Egypt)

Retinal Structural Changes in Parkinson’s Disease: insight into GBA1-Related PD and non-mutated PD

G. Di Rauso, M. Giacomelli, G. Portaro, S. Grisanti, V. Fioravanti, L. Caprari, G. Toschi, G. Argenziano, R. Sabadini, L. Taruffi, A. Scaglioni, E. Monfrini, A. Di Fonzo, M. Vecchi, F. Cavallieri, F. Valzania (Reggio Emilia, Italy)

Returning Secondary Health Findings in the PD GENEration study

M. Dini, K. Ghosh Galvelis, N. Bothwick, L. Caboy, M. Caulfield, R. de Leon, A. Dilliott, I. Khaderi, S. Rao, A. Yake, A. Coral Zambrano, R. Bhisetti, S. Lawrence, S. Li, Y. Lu, U. Ragunathan, T. Foroud, V. Caceres, L. Cook, K. Fiallos, L. Heathers, R. Hodges, A. Miller, A. Neibaur, M. Rumbaugh, M. Totten, J. Verbrugge, A. Hall, K. Marder, I. Mata, N. Mencacci, M. Nance, T. Simuni, M. Schwarzschild, A. Wills, H. Gao, C. Blauwendraat, J. Beck, R. Alcalay (Miami, USA)

Revealing Novel Genetic Contributors to Parkinson’s Disease in a Chinese Cohort: An Elaborate Examination within the CPD10KGP

Z. Liu, Y. Zhao, H. Pan, B. Tang (Changsha, China)

Screening for GBA1 p.K198E PD-Risk Variant in Latin America

J. Ramchandra, E. Waldo, L. Santiago, TP. Leal, T. Lopez-Gonzalez, M. Inca Martinez, C. Velez-Pardo, D. Pineda, M. Jimenez-Del-Rio, F. Lopera, S. Moreno, O. Buritica, J. Orozco, B. Muñoz Ospina, M. Camacho, G. Arboleda, H. Arboleda, O. Bernal, CE. Arboleda-Bustos, IF. Mata (Cleveland, USA)

Sex-Dependent Associations Between PGLYRP2 Variants and Parkinson’s Disease Across Diverse Ancestries

HM. Chaparro-Solano, CL. Avila, V. Quintana-Peña, KA. Brolin (Cleveland, USA)

Sex-specific genetic architecture of autosomal risk for Parkinson’s Disease: from the Global Parkinson’s Genetics Program

GP2. Parkisnon'S_genetics_program (Bethesda, USA)

Smoking and Genetic Interactions in Parkinson’s Disease

JDJ. Wang, LL. Chan, E. Ng, K. Prakash, WL. Au, L. Tan, EK. Tan (Singapore, Singapore)

Studying the Influence of Genetic Variations on Functional Performance in Parkinson’s Disease

D. Moss, K. Smaller, M. Rafferty, P. Gonzalez-Latapi (Chicago, USA)

The Genetic Landscape of Parkinson’s Disease in African and Admixed Populations: Discovering Population-Specific Risk and Unveiling Etiological Insights

O. Ojo, N. Okubadejo, M. Makarious, S. Bandres-Ciga (Lagos, Nigeria)

The Global Parkinson’s Genetics Program: Expanding the Diversity of Neurological Disorder Data: 2025 Update

GP2. Parkinson'S_genetics_program (Chevy Chase, USA)

The regulatory variant c.–253C>T of the DNAJC13 gene as a causal factor for Parkinson’s disease in a patient with early-onset

J. Hoenicka, A. Pascual, P. García-Ruíz, X. Castro-Martínez, R. Repossi, O. de Fabregues, L. Vela-Desojo, M. Mata, I. Torres, JC. Martinez-Castrillo, F. Palau, G. Fernandez (Mexico City, Mexico)

The Role of Polygenic Background and APOE E4 in Monogenic and Idiopathic Parkinson’s Disease

M. Kmiecik, M. Holmes, P. Fontanillas, G. Riboldi, R. Schneider, J. Shi, A. Guan, S. Tat, K. Stagaman, J. Gottesman, D. Hinds, J. Tung, S. Aslibekyan, L. Norcliffe-Kaufmann (Sunnyvale, USA)

Unveiling Parkinson’s Disease Variants in the Chinese Population: The CPD10KGP Study

Y. Zhao, Z. Liu, H. Pan, J. Guo, B. Tang (Changsha, China)

Using Multi-Generational High-Risk Pedigrees to Identify Candidate Parkinson’s Disease Predisposition Genes

P. Moretti, K. Allen-Brady, J. Stevens, K. Figueroa, S. Pulst, L. Cannon-Albright (Salt Lake City, USA)

Utilizing the Global Parkinson’s Genetics Program (GP2) to develop a precision medicine recruitment protocol

K. Atterling Brolin, YY. Beh, P. Saffie Awad, J. Aviles, A. Pajo, E. Navarro-Jones, C. Klein, I. F. Mata, K. Paquette, H. Iwaki, L. Jones, H. Leonard, N. Okubadejo, C. Blauwendraat, L. Screven, A. Noyce, M. Toffoli, AH. Tan, H. Morris, M. Nalls (Lund, Sweden)

VPS13C: a Modifier Gene causing Suboptimal Response to Levodopa in Early-Onset Parkinson’s Disease

L. Malfer, C. Piat, O. Ross, Z. Niu, E. Benarroch, R. Savica (Jacksonville, USA)

VPS35-Related Parkinson Disease in a Patient of Korean Ancestry: A Case Report

B. Yasuda, M. Bruno (Honolulu, USA)

Whole Genome Sequencing of an Early-onset Malaysian Parkinson’s Disease Cohort

YW. Tay, TS. Toh, JW. Hor, JL. Lim, KA. Ibrahim, AS. Mawardi, TT. Lim, I. Looi, YK. Chia, JCE. Ooi, WC. Law, J. Wong, YH. Lau, PC. Teh, TL. Ong, WK. Cheah, LC. Lit, KA. Muthusamy, L. Lange, KL. Lohmann, ZH. Fang, CK. Klein, AA. Ahmad-Annuar, SY. Lim, AH. Tan (Kuala Lumpur, Malaysia)