Immunological causes of atypical parkinsonism
Objective: To study the clinical and biochemical features of atypical parkinsonism. Evaluate results of the immune-mediated treatment Background: Atypical parkinsonism is a heterogeneous group of…Cerebrospinal fluid levels of cytokines in multiple system atrophy: A cross-sectional study of the atalan msa registry (CMSAR)
Objective: To compare the cerebrospinal fluid (CSF) levels of 38 cytokines in multiple system atrophy (MSA) patients vs. control and Parkinson’s disease (PD) subjects. Background:…Patterns of dopamine transporter imaging in subtypes of Multiple System Atrophy
Objective: To investigate the differences in the pattern of striatal (caudate and putamen) dopamine transporter(DAT) loss in a multiple system atrophy (MSA) cohort, based on…The etiologies of chronic progressive cerebellar ataxia in a Korean population
Objective: The etiologies and frequency of cerebellar ataxias vary among countries. Our primary aim was to assess the frequency of each diagnostic group of cerebellar…Apolipoprotein E and multiple system atrophy
Objective: This study evaluated genetic associations of Apolipoprotein E alleles with risk of multiple system atrophy (MSA) and α-synuclein pathology, and also examined whether apolipoprotein…Serum fractalkine levels in Parkinson’s disease: Evidence for neuroinflammation
Objective: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by loss of dopamine neurons in the substantia nigra. We measured neuroinflammatory marker fractalkine in…PROMESA: A randomised, double-blind, placebo-controlled trial to evaluate the progression rate of MSA under EGCG supplementation as anti-aggregation-approach
Objective: To evaluate the safety and tolerability of epigallocatechin gallate (EGCG) in high doses and its efficacy to slow down disease progression in patients with…α-Synuclein Preformed Fibrils Induce Disruption of Myelin Basic Protein Expression in Primary Oligodendrocyte Culture; Deciphering Glial Pathology in Multiple System Atrophy
Objective: This research focuses on the impact of extracellular α-synuclein preformed fibrils (α-syn PFFs) on oligodendrocytes (OLGs) as a potential contributor exacerbating the pathology of…Mutational analysis of COQ2 in Chinese patients with multiple-system atrophy
Objective: To investigate the involvement of COQ2 variants in Chinese sporadic cases with multiple-system atrophy. Background: Multiple-system atrophy (MSA) is a rapidly progressive neurodegenerative disease…Gut Microbiota in Multiple System Atrophy
Objective: To investigate the gut microbiome and metabolome in MSA Background: Experimental models of prion-like cell-to-cell transfer of alpha-synuclein(AS) and its ability to spread from the…
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