Patient-Specific Outcomes of Transcutaneous Afferent Patterned Stimulation with Varying Frequencies for Essential Tremor and Parkinson’s Disease
Objective: Two studies were conducted to compare the safety, effectiveness, and comfort of fixed- and variable-frequency transcutaneous afferent patterned stimulation (TAPS) for action tremor relief…The mGlu2 positive allosteric modulator BINA extends enhances low dose L-DOPA anti-parkinsonian action in the MPTP-lesioned marmoset
Objective: To determine the effect of positive allosteric modulation of the metabotropic glutamate type 2 (mGlu2) receptor in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset using a low…Mapping of the International Classification of Functioning, Disability and Health categories in the Pre-Assessment Information Form for People with Parkinson’s Disease.
Objective: Perform the linkage between the items of the Pre-Assessment Information Form (PAIF) of the people with Parkinson's Disease (pPD) with the categories of the…Microglial activation facilitates alpha synuclein propagation and neurodegeneration in αSyn preformed fibrils (PFF)-injected PD mouse model
Objective: To evaluate whether microglial activation aggravates synucleinopathy progression in Parkinson's disease (PD) mouse model. Background: Alpha-synuclein (αSyn) accumulation underlay the main pathological process of…Machine learning supervised classification study for Parkinson`s disease progression through graph-based feature selection method
Objective: The model helps neuro physicians/ neurologists to improve the PD symptoms, or therapeutic-treatment planning-procedures. Background: Artificial intelligence-based machine learning (AI-ML) supervised classification systems have…Beyond the subthalamic nucleus: tractography patterns of Magnetic Resonance-guided Focused Ultrasound subthalamotomy
Objective: To identify subthalamic clusters that predict maximum improvement in bradykinesia, rigidity and tremor. To map-out the cortical fingerprint, which predict maximum efficacy. Background: Subthalamotomy…Striatal Blood brain barrier opening in Parkinson´s disease
Objective: To test safety and feasibility of repeated low-intensity focused ultrasound (FUS) blood brain barrier opening (BBB) in the striatum of Parkinson’s disease (PD) patients.…Identification and clinical characterization of GBA variants in the Luxembourg Parkinson’s Study
Objective: Assess the entire set of variants in the glucocerebrosidase (GBA) gene by long-read sequencing in the Luxembourg Parkinson’s study (LuxPARK) and characterize genotype-phenotype correlations…Corticobasal syndrome and Parkinson’s disease at the beginning: usefulness of different asymmetrical patterns for early diagnosis.
Objective: To evaluate R2 Blink Reflex Recovery Cycle (R2BRRC) and cortical thickness in drug-naïve PD patients and in CBS patients for characterizing pathophysiological mechanisms underlying…Association of a new pathogenic variant of LRRK2 with modifying lysosomal genes in a family with Parkinson’s disease
Objective: To characterize a Parkinson’s disease (PD) family with high recurrence of the disease. Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder in which…
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