Differences Between Clinical and Imaging Phenotypes in Phase 2 Study of ATH434 in Multiple System Atrophy
Objective: To assess differences between clinical and imaging phenotypes in Multiple System Atrophy (MSA) and evaluate the reliability of imaging biomarkers for subtype classification. Background:…Spatial Metabolic Covariance Networks in PSP: Implications for Symptomatology and their Neural Basis
Objective: This study aimed to apply spatial ICA to 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) data from PSP patients and healthy controls (HCs) to identify…Exploring Cardiac Autonomic Dysfunction in Synucleinopathies with Parkinsonism Across Awake-Sleep Stages
Objective: To explore the differences in heart rate variability (HRV) across awake-sleep stages between patients with synucleinopathies and elderly controls without parkinsonism Background: A complex…Rethinking Parkinsonism: Limitations in Clinical Diagnosis
Objective: To highlight the limitations in clinically differentiating PD and MSA. Background: The antemortem differentiation of parkinsonian syndromes remains challenging due to overlapping symptomatology, particularly…Resolution Dependence of Machine Learning for Differential Diagnosis of Parkinsonian Eye Movements
Objective: To establish the extent to which high temporal resolution is required to differentiate between parkinsonian disease states from eye movements. Background: Previous studies have…Improved Decision-Making for In-Hospital Medication Management in Parkinson’s Disease
Objective: To enhance clinical decision-making in PD management by developing and validating a conformal prediction framework that forecasts Levodopa Equivalent Daily Dose (LEDD) changes with…The Role of FGF14 GAA Repeat Expansions in Multiple System Atrophy: Frequency, Phenotypic Correlations, and Prognostic Implications
Objective: This study aimed to investigate the frequency of FGF14 GAA•TTC repeat expansion in clinically diagnosed and pathologically confirmed multiple system atrophy cases. Background: Partial…Carbidopa/levodopa related hypotension in patients with alpha-synucleinopathies
Objective: Evaluate blood pressure response to levodopa/carbidopa in patients with synucleinopathies undergone to autonomic testing. Background: Carbidopa/levodopa is the mainstay treatment of patients with synucleinopathies,…A Randomized, Double-blind Phase 3 Trial of Amlenetug Versus Placebo in Patients with MSA: The MASCOT Trial
Objective: Describe the protocol for a randomized, double-blind phase 3 trial evaluating the efficacy and safety of amlenetug versus placebo in slowing clinical progression in…Machine Learning Model using Eye Movements for the Differential Diagnosis of iPD and Atypical Parkinsonian Syndromes
Objective: To develop a machine learning (ML) model to first between differentiate between healthy controls, idiopathic PD, Atypical Parkinsonian syndromes and then further subclassify as…
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