2026 International Congress » Parkinson's Disease: Pathophysiology / molecular mechanisms of disease

Meeting: 2026 International Congress

Activation of the MT1 Receptor Ameliorates Mitochondrial Dysfunction in MPP+/MPTP-Induced Parkinson’s Disease

LL. Qi, CF. Liu, F. Wang (Suzhou, China)

Aggregation – Dependent Effects of Wild-Type and Mutant α-Synuclein on Synaptic Membrane Fusion

M. Sriram, D. Rege, A. Das, R. Nellikka, D. Das (Mumbai, India)

Altered Diet–Microbiome Associations in Parkinson’s Disease and Prodromal REM Sleep Behavior Disorder

S. Jo, J. Lee, H. Im, M. Choi, G. Lee, S. Chung (Seoul, Republic of Korea)

Altered Glia Limitans Structure and Function in Parkinson’s Disease and Multiple System Atrophy

L. Wang (Shanghai, China)

An Optimized Workflow for High-Throughput RNA-Seq from Human Deep Brain Tissue Using DBS Microelectrodes

S. Xxxx, A. Saini, V. Chouhan, S. Rai, D. Radhakrishnan, E. A, D. Garg, A. Das, S. Kumar, A. Yadav, A. Garg, R. Bhatia, A. Shariff, A. Srivastava, D. Savarakar, R. Kumar, M. Singh, K. Garg, P. Chandra, R. Rajan (New Delhi, India)

Analysis of Sphingolipid Metabolism Gene Expression in the Parkinson’s Disease Postmortem Brain Dataset

JL. Li, CH. Lin (New Taipei City, Taiwan)

Assessment of α-Synuclein Seeding Activity in the Olfactory Mucosa after SARS-CoV-2: a Pilot Study

B. Heim, K. Seppi, N. de Cleene, M. Bongianni, E. Bronzato, C. Cerejo, F. Jagusch, P. Kindl, J. Loeffler-Ragg, G. Weiss, T. Gottfried, J. Schmutzhard, G. Zanusso, W. Poewe (Innsbruck, Austria)

Association of MT-ATP6 Polymorphisms with Increased Reactive Oxygen Species and Biomarker Alterations in Parkinson’s Disease

B. Chandar, HSB. Suresh Babu, NR. Raj, MB. Balachandar, VL. Lakhanpal (Bathinda, India)

Astrocyte Derived Extracellular Vesicle miR 210 Expression in Exenatide Treated Patients with Parkinson’s Disease

A. Keshavaprasad, I. Markaki, P. Svenningsson, S-B. Catrina, X. Zheng (Linköping, Sweden)

Baicalein Attenuates Rotenone-Induced Neurodegeneration by Regulating BDNF/CREB/Akt Signaling in Parkinson’s Disease

A. Singh (Solan, India)

Cerebellar α-Synucleinopathy Contributes to Gait and Balance Impairment in Parkinson’s Disease

T. Li, Q. Qiu (Dalian, China)

Cerebrospinal Fluid Metabolic Alterations Reveal a Central Energy Metabolism Shift in Parkinson’s Disease

R. Nagao, Y. Mizutani, R. Ohdake, Y. Maeda, J. Yoshimoto, K. Kawabata, S. Shima, Y. Seino, M. Ito, A. Suzuki, H. Watanabe (Toyoake, Japan)

Cerebrovascular reactivity in Parkinson’s disease: acute effects of Levodopa assessed by transcranial doppler

F. Garramone, D. Rinaldi, I. Madonia, M. Sforza, V. Teresi, E. Bianchini, L. de Carolis, S. Galli, P. Pacilio, P. Lombardo, M. Salvetti, G. Sette (Rome, Italy)

Cortical Disinhibition and Beta Hypersynchrony underlying Freezing of Gait in Parkinson’s Disease: a TMS–EEG Study

HM. Sun, KZ. Zhang (Nanjing, China)

DDX17 Drives Astrocytic Mitochondrial Metabolic Reprogramming and Contributes to Parkinson’s Disease Progression

XIA. Dong, GAN. Wu, XIN. Yang, QIN. Li, FUR. Jin, RUI. Li, HON. Li, RUI. Xu (kunming, China)

Dentate Glutamate as an OFF-State Biomarker of Levodopa-Resistant Postural Tremor in Parkinson’s Disease

S. Prasad, A. Xavier, D. Deelchand, M. Kumar, R. Yadav, P. Pal, J. Saini (Bengaluru, India)

Differential Microglial Activation and p-Ser129 Alpha-Synuclein Induction by Neurotropic and Non-Neurotropic Influenza A Virus Strains

L. Ho, D. Nguyen, E. Ko, Y. Kim (Jeju, Republic of Korea)

Disrupted Lipid Homeostasis and Mitochondrial Remodeling in A53T α-Synuclein Astrocytes

I. Goglia, SL. Pereira, M. Tziortziou, P. Mulica, S. Delcambre, L. Gallucci, L. Neises, M. Mendes, G. Dittmar, J. Meiser, A. Monzel, E. Glaab, A. Grünewald (Belvaux, Luxembourg)

Early Complement Activation Prunes Inhibitory Synapses in Prodromal Synucleinopathy Independent from Lewy Pathology.

S. Rumpf, F. Strübing, K. Nalbach, C. Vargi, S. Lichtenthaler, P. Parchi, P. Gao, W. Chen, M. Brendel, J. Gnörich, A. Bernhardt, G. Höglinger, J. Herms, T. Koeglsperger (Munich, Germany)

Effects of Chronic IEM-1460 Treatment on Perineuronal Net–Parvalbumin Interneuron Association in L-DOPA-Induced Dyskinesia

NT. Bilbay, EN. Kaptan, C. Cakir-Aktas, G. Yalcin-Cakmakli, B. Elibol, BC. Tel (Ankara, Turkey)

Extracellular vesicle–based characterization of synaptic dysfunction in early Parkinson’s disease

L. Kurvits, C. van Riesen, J. Rhee (Göttingen, Germany)

GBA1 deficiency promotes tau and TDP-43 co-pathology

A. Park, L. Lee, M. Kim, M. Callier, E. Chiu, C. Latimer, M. Davis (Seattle, USA)

GBA1 L444P mutation increases susceptibility to neuroinflammation and promotes pro-inflammatory immune responses

R. Wang, D. Cossu, Y. Tomizawa, T. Hatano, N. Hattori (Bunkyo, Japan)

Gelsolin and Secretogranin-3 induce Parkinsonian features in rodent models.

R. Raghu, S. Choudhury, P. Alladi (Bengaluru, India)

Human Snca Knock-In Mouse as a Model for Synucleinopathy Research

E. Cinar, J. Ma, Y. Liang, K. Luk (Philadelphia, USA)

Impact of Alpha-Synuclein Burden and Cellular Stress on GBA-PD Macrophage

V. Lentini, G. Uras, D. Moreno-Martinez, S. Lucas, A. Pantaleo, D. Hughes (London, United Kingdom)

Insight into α-synuclein pathogenicity by a human cell model with suppressed NatB-mediated N-terminal acetylation

A. Caiella, E. Timmerman, M. Lundekvam, N. Glomnes, T. Hjellvoll, F. Impens, H. Aksnes, T. Arnesen (Bergen, Norway)

Integrating Transcriptomics and Morphological Profiling to Characterize GBA-Associated Parkinson’s Disease in Midbrain Organoids

F. Nasta, E. Glaab, JC. Schwamborn (Esch-sur Alzette, Luxembourg)

Intestinal Dysbiosis in Parkinson’s Disease: Mechanisms, Clinical Implications, and Therapeutic Perspectives (2015–2025)

H. Harifi (Kenitra, Morocco)

Investigating Phospho-α-Synuclein Pathology in Patient-Specific Microglia Integrated into Midbrain Organoids

E. Zuccoli, H. Kurniawan, JC. Schwamborn (Esch-sur Alzette, Luxembourg)

Investigating Subthalamic Neuronal Activity in Parkinsonian Patients with Hemidystonia

P. Pavlovsky, A. Golik, A. Gamaleya, A. Tomskiy, A. Sedov, E. Belova (Moscow, Russian Federation)

Irisin as a Molecular Mediator of Exercise Induced Neuroprotection and Disease Modification in Parkinson’s Disease

NIK. Choudhary (Jodhpur, India)

Iron-independent initiation of neurodegeneration in BPAN

S. Noda, N. Hattori (Bunkyo, Japan)

Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease

P. Thakur, U. Agarwal (Thiruvananthapuram, India)

Macrophage Subtypes in Brainstem Catecholamine Regions in Healthy Ageing and Across Parkinson’s Disease.

A. Filimontseva, S. Gonzalez, Y. Fu, G. Halliday (Chevy Chase, USA)

Mechanisms of PLA2G6 Deficiency Impacting Mitochondria-associated membranes in Parkinson’s Disease

JB. Liu, BS. Tang, JQ. Tan, JF. Guo (Changsha, China)

Mechanistic study of PARP9-mediated mitochondrial transfer in regulating dopaminergic neuronal injury and neuroinflammation in Parkinson’s disease

L. Liao, Z. Zhang (Guangzhou, Guangdong Province, China)

Micro- and Nanoplastics in Parkinson’s Disease Pathogenesis An Emerging Environmental Risk Factor

A. Aralbayeva, Z. Akhmetzhanova, A. Baidarbekova (Astana, Kazakhstan)

Midbrain Organoid Modeling and Transcriptomic Characterization of NOTCH2NLC GGC Repeat Expansion–Associated Parkinson’s Disease

H. Qian, Y. Chen, W. Wei (Hangzhou, China)

Modeling the Genetic Complexity of Parkinson’s Disease: Generation of Patient-Specific iPSCs with Co-occurring SNCA/GBA1 and PRKN/LRRK2 Variants

L. Murillo-Hernández, M. Bonilla-Toribio, D. Buiza-Rueda, P. Gomez-Garre, L. Muñoz-Delgado, P. Mir, R. Mejías, A. Fontán-Lozano (Sevilla, Spain)

Monocyte and T-cell Immunological Profiles of Asian LRRK2 Variants G2385R And R1628P in Parkinson’s Disease: Associations with Clinical Measures

NJ. Zulkefli, NJ. Zulkefli, NS. Zulhaimi, HX. Ding, TS. Toh, JW. Hor, YW. Tay, AN. Khairul Anuar, JL. Lim, JW. Goh, RY. Ong, QH. Yong, A. Ahmad Annuar, LC. Lit, SY. Lim, R. Rajasuriar, AH. Tan (Kuala Lumpur, Malaysia)

Multi-Omics Analysis Reveals Brain and Biofluid Molecular Changes Induced by Chronic Sleep Fragmentation in a Prodromal Parkinson’s Disease Mouse Model

H. Yagihara, M. Miyazaki, K. Ueda, H. Yamakado, E. Minakawa (Tokyo, Japan)

Neurofilament Light Chain Triggers Protein Aggregation, Neurotoxicity and Gliosis in Parkinson’s Disease through p38/MK2/NF-κB/CREB1 and Nrf2/HO-1 Signalling

A. Nanda, RK. Singh (Lucknow, India)

Non-Motor Phenotypes and Intestinal Microbiome Alterations in GBA1-Associated Parkinson’s Disease: Evidence for a Body-First Subtype

I. Miliukhina, E. Kryukova, S. Pchelina (Saint-Petersburg, Russian Federation)

Patient-Derived α-Synuclein Kinetic Subtypes Drive Distinct Pathological Propagation Patterns and Brain Network Alterations in Parkinson’s Disease Mouse Models

W. Dai (Urumqi, China)

Prosaposin differentially modulates lipid metabolism of striatal and non-striatal dopamine D1 receptor-expressing neurons and regulates L-DOPA-induced dyskinesia

Y. He, I. Kaya, Y. Yang, A. Nilsson, R. Shariatgorji, I. Mantas, X. Zhang, P. Andren, P. Svenningsson (Solna, Sweden)

Raman Spectroscopic Identification of Biochemical Alterations in Post Mortem Brain Tissue Microarrays from Parkinsons and Alzheimers Disease

A. Omirude, A. Yusuf, S. Eze (Zaria, Nigeria)

Regional α-Synuclein Seeding Activity in Parkinson’s disease and Multiple System Atrophy

D. Kim, D. Yoo, S. An, M. Kang, T. Ahn (Seoul, Republic of Korea)

Senile Plaques and Neurofibrillary Tangles Modulate Lewy Body Distribution: Autopsy Study of 2,308 Cases

H. Sekiya, D. Ono, D. Dickson (Jacksonville, USA)

Sex differences for clinical impact of APOEe4 mediated by Alzheimer’s pathology in people with Lewy body pathology

E. Bayram, B. Bettcher, S. Holden (Aurora, USA)

Single-Cell Transcriptomics and Experimental Models Implicate Functional Hypoxia in Microglial DAM Polarization and α-Synuclein Accumulation, with Involvement of HIF-1α, in Parkinson’s Disease

H. Wang, Z. Zhu, Z. Yin, K. Zhang (Nanjing, China)

Single-Neuron Analysis of Mitochondrial DNA Alterations and Respiratory Chain Dysfunction in Parkinson’s Disease

A. Rubiolo, S. Geithus, S. Mostafavi, C. Dölle, I. Flønes, C. Tzoulis (Bergen, Norway)

Skin Tau Quantification as a Potential Degeneration Biomarker in Parkinson’s Disease

J. Rodriguez-Antiguedad, A. Puig-Davi, A. Vazquez-Oliver, E. Rivas-Asensio, E. Vacchi, G. Melli, L. Bojtos, C. Franch-Marti, S. Martinez-Horta, J. Pagonabarraga, J. Kulisevsky (Barcelona, Spain)

Stage-Dependent Dysregulation of Peripheral TREM2, SOD1, and Neurofilament Light Chain Across the Parkinson’s Disease Continuum

A. Calculli, D. Di Martino, R. Stiuso, H. Ferrari, C. Fazio, D. Comolli, P. Grillo, N. Polverino, M. Mancini, A. Pisani (Pavia, Italy)

Stimulation Amplitude Asymmetry in Subthalamic Deep Brain Stimulation Affects Freezing of Gait During Gait Adaptation in Parkinson’s Disease

I. Hanafi, N. Pozzi, G. Pezzoli, J. Volkmann, I. Isaias, C. Palmisano (Würzburg, Germany)

STN Neuronal Activity Shows Complex and Patient-Dependent Differences in Akinetic-Rigid Parkinson’s Disease With and Without Dystonia

A. Golik, P. Pavlovsky, A. Gamaleya, A. Tomskiy, A. Sedov, E. Belova (Moscow, Russian Federation)

Study on the Mechanism of SIRT3 Protecting Parkinson’s disease by Regulating Mitophagy

NW. Hu, M. Zhang, HM. Cao, QM. Qu (Xi'an, China)

Substantia Nigra Free-Water, Metabolic Markers, and Motor Variability in Older Adults with Diabetes

A. Belnavis, S. Chiu, K. Chen, J. Klein-Seetharaman, E. Ofori (Tempe, USA)

Targeting c-Abl/Drp1-Dependent Mitochondrial Fission: Neuroprotective Effects of Berberine Chloride in Parkinson’s Disease Models

D. Khatri (Chandwaji, Jaipur, India)

Targeting the Immunoproteasome PSMB8: A dual strategy to enhance α-synuclein clearance and mitigate CD8+ T-Cell neurotoxicity in Parkinson’s Disease

HD. Nguyen, HBT. Tran, TT. Nguyen, IH. Kwak, YJ. Kim, H. Ma, HJ. Kim, YE. Kim (Anyang, Republic of Korea)

Targeting the NLRP3 Inflammasome by PD180970 Based on Differential Susceptibility to MPTP

S. Choudhury, M. Srinivas Bharath, R. Yadav, P. Alladi (Bangalore, India)

The “Sequestration” hypothesis: Longitudinal systemic priming and CNS infiltration of Neutrophil Extracellular Traps in Parkinson’s Disease

HD. Nguyen, S. Lee, H. Ma, YJ. Kim, HJ. Kim, YE. Kim (Anyang, Republic of Korea)