2025 International Congress » Parkinson's Disease: Pathophysiology / molecular mechanisms of disease

Meeting: 2025 International Congress

A Biomarker-Directed Approach to the Early Diagnosis of Parkinson’s Disease Using Artificial Intelligence and Machine Learning

ME. Mellaci (SÃO PAULO, Brazil)

A Long-Living Human Tissue Engineered Nigrostriatal Pathway as a Testbed to Study Parkinson’s Disease

D. Chouhan, A. Bello, K. Cullen, J. Duda (Philadelphia, USA)

A Study Of Axial Postural Abnormality In Parkinson`s

V. Rama Raju (Hyderabad, India)

Alpha-Synuclein Accumulation-Attenuating Effect of Brain-Derived Neurotrophic Factor in Primary Cell Culture Model of Parkinson’s Disease

I. Hlushchuk, MT. Airavaara (Helsinki, Finland)

Alterations of Plasma Membrane in Parkinson’s disease LRRK2 I1371V iPSC derived Astrocytes contribute to the vulnerability of the niche cells to Extracellular α-Synuclein

I. Datta, R. Banerjee, V. Holla, N. Kamble, R. Yadav, P. Pal (Bengaluru, India)

Amygdala-predominant Lewy Body Disease is a Lens for Understanding Pathogenesis and the Alpha-synuclein Seeding Assay in Human Postmortem Brain

D. Fischer, L. Vandevrede, W. Seeley, S. Spina, S. Li, W. Lee, T. Lamore, F. Wekselman, A. Lario Lago, L. Grinberg (San Francisco, USA)

Bassoon (BSN) Gene Mutations: A Missing Link in Gait and Balance Dysfunction Across Parkinsonian Disorders?

P. Kukkle, A. Kaladiyil, T. Geetha, R. Menon, R. Kandadai, V. Goyal, S. Desai, D. Joshi, H. Kumar, P. Wadia, A. Mukherjee, N. Kumar, S. Mehta, S. Chargulla, S. Murugan, H. Shah, V. Paramanandam, M. Chandran, R. Yadav, R. Dhamija, P. Pal, A. Biswas, R. Gupta, R. Borgohain, V. Ramprasad (Bengaluru, India)

Bone Mineral Density in Early Parkinson’s Disease: Correlations with Disease Severity and Prognosis

MG. Choi, SY. Jo, JY. Lee, SJ. Chung (Seoul, Republic of Korea)

Boosting the LTP-like Plasticity Effect of Intermittent Theta-burst Stimulation with Gamma Transcranial Alternating Current Stimulation improves Bradykinesia in Parkinson’s Disease

G. Paparella, D. Costa, M. de Riggi, L. Angelini, A. Cannavacciuolo, S. Pietracupa, A. Berardelli, A. Guerra, M. Bologna (Pozzilli

Cell-type specific bidirectional modulation of STN neurons rescue Parkinsonian motor symptom.

JH. Shin, HK. Chung, JH. Kim, JS. Yook, J. Kim, B. Jeon (Seoul, Republic of Korea)

Characterising Peripheral Innate Immune Cell Infiltration into the Brain in Parkinson’s Disease

C. Tournerie, B. Patel, A. Quaegebeur, C. Williams-Gray (Cambridge, United Kingdom)

Characterization of the Dnajc13 p.N860S mouse model, a physiological model of alpha-Synuclein overexpression

J. Follett, J. Fox, I. Deng, S. Wall, A. Rajput, A. Rajput, M. Farrer (Gainesville, USA)

Complement C4 Exacerbates Inflammation and Neuronal Damage in Vivo

W. Zou, Y. Wang, Y. Xia, L. Kou, T. Wang (wuhan, China)

Contribution of Dopamine Depletion, Cerebral Perfusion, and Cognition to Gait Dysfunction in Parkinson’s Disease

HK. Na, CW. Park, Y. Sun, JH. Lee, YY. Choi, SJ. Chung, YH. Sohn, CH. Lyoo, PH. Lee (Seodaemun-gu, Republic of Korea)

Deferiprone improves striatal dopamine by reducing neuroinflammation and oxidative stress in MPTP-induced mice model of Parkinson’s disease

HSA. Olasore, JO. Faleti (Lagos, Nigeria)

Differential Effect of alpha-Synuclein on Mitochondrial Morphology in PD and MSA

O. Driskill, E. Ostrakhovitch, J. Patel, J. Stegemann, T. Yamasaki (Lexington, USA)

Differential Effect of Dopaminergic Treatment on Bradykinesia Features and Limb-kinetic Apraxia in Parkinson’s Disease

M. de Riggi, G. Paparella, A. Cannavacciuolo, D. Birreci, D. Costa, M. Passaretti, L. Angelini, M. Bologna (Rome, Italy)

Differentiating Parkinsonism and related diseases by specific Parkinsonism patterns

JX. Wang, B. Wang, XH. Chen, W. Luo (Hangzhou, China)

Distinct roles of PARK2, PINK1, and LRRK2 in neuroinflammation: resistance and susceptibility in immune-mediated mouse models

D. Cossu, H. Okada, S. Noda, Y. Tomizawa, S. Ueno, L. Sechi, T. Hatano, N. Hattori (Tokyo, Japan)

Dynamics Of Pallidal Beta Activity During Voluntary Movement In Parkinson’s Disease And Cervical Dystonia

V. Filyushkina, S. Usova, A. Gamaleya, A. Tomskiy, A. Sedov (Moscow, Russian Federation)

Early Impairment in the Immunomodulatory Function of Mesenchymal Stromal Cells Contributes to Heightened Peripheral and Neuroinflammation in Parkinson’s Disease Insights From In Vivo Chronic PD Rat Model and In Vitro PD iPSC Model

R. Ghanty, I. Datta, G. Wagmare, N. Kamble, PK. Pal, V. Holla, R. Yadav, K. Mondal (Bengaluru, India)

Effect of Aβ on α-synuclein propagation

Y. Narumiya, E. Nakanishi, T. Taguchi, M. Sawamura, N. Uemura, T. Maki, T. Saito, R. Takahashi, R. Matsumoto, H. Yamakado (Nagoya, Japan)

Elucidating Tau and Alpha-synuclein Co-pathology in RAB39b X-linked Parkinson’s Disease.

M. Kim, A. Park, E. Chiu, J. Weiss, S. Yu, D. Yearout, C. Zabetian, O. Betancour, M. Davis (Seattle, USA)

Establishing a Timeline of Non-Motor and Motor Symptoms Progression in Parkinson’s Disease Using a Sub-Chronic MPTP Mouse Model

M. Chopra, A. Sekar, R. Hussain, L. Diwakar (Bengaluru, India)

Exploring Neuroprotective Role of Natural Compound by Targeting c-Abl Kinase in Parkinson’s Disease

D. Khatri (Chandwaji, Jaipur, India)

Exploring the ubiquitome in Parkinson’s Disease

A. Yeung, SA. Cobbold, M. Li, GK. Smyth, L. Wang, JR. Han, IKL. Tan, M. Bahlo, AH. Evans, D. Komander, S. Masaldan, G. Dewson (Melbourne, Australia)

Fatty Acid Metabolic Reprogramming Regulates Glial-Epithelial Axis via Nur77 Palmitoylation in Intestinal Dysfunction in Parkinson’s Disease

J. Zou, Z. Deng, Z. Lu, X. Luo, F. Yu, W. Bi (Guangzhou, China)

Findings of motoric and neuro psychological outcome using high frequency stimulations in Parkinsons with STN-DBS

A. Dabbeta, V. Rama Raju (Hyderabad, India)

GBA1 deficiency promotes the spread of Lewy pathology

S. Fish, A. Park, J. Weiss, M. Kim, E. Chiu, M. Callier, S. Yu, M. Davis (Seattle, USA)

GCase and Ganglioside GM1 Interaction in Parkinson’s Disease

F. Fierli, G. Uras, S. Lucas Del-Pozo, S. Koletsi, V. Lentini, A. Schapira (London, United Kingdom)

Glial interaction with Parkinsonian disorders biomarkers: alpha-synuclein, dopaminergic dysfunction and clinical stages

L. Souza, D. Teixeira, G. Pereira, E. Zimmer, W. Borelli, A. Schuh (Porto Alegre, Brazil)

Influence of Gut Microbiota-Derived TMAO on Disease Severity in Parkinson’s Disease

S. Virameteekul (Bangkok, Thailand)

Investigating the role of NLRP3 Inflammasome as Biomarkers and Therapeutic Targets in Parkinson’s Disease Pathogenesis

S. Choudhury, N. Kamble, V. Holla, S. M, P. Pal, R. Yadav, P. Alladi (Bangalore, India)

Lewy Pathology correlates with neuroinflammation in the hippocampus of Synucleinopathy patients in a subregion specific manner

E. Luna, K. Cousins, S. Emrani, K. Luk, V. Lee, E. Lee, D. Weintraub, S. Xie, A. Chen-Plotkin, F. Bennett, D. Irwin (Philadelphia, USA)

LRRK2 I1371V Mutation Induces ER Stress, Mitochondrial Dysfunction, and Impaired Mitophagy in Parkinson’s Disease Astrocytes

R. Banerjee, V. Holla, N. Kamble, R. Yadav, P. Pal, I. Datta (Bangalore, India)

Mass spectrometry-based screening for α-synuclein bioactive marine natural products

F. Ferretti, M. Xu, D. Prebble, G. Mellick, A. Carroll (Gold Coast, Australia)

Mathematical and Computational Modeling Prototype to Understand the Evolution of Parkinson’s disease using Four Differential Equations

G. Sa, A. Rodrigues Tavares, M. Silva Bissaco (Mogi das Cruzes, Brazil)

Metabolomic Profiling in an Egyptian Cohort Reveals Altered Phenylalanine Metabolism and Suggests a Role for Trans-Cinnamate in Parkinson Disease

N. Shebl, S. El-Jafaary, A. Saeed, P. Elkafrawy, A. El-Sayed, S. Shamma, R. Elmer, J. Mekky, L. Mohamed, O. Kittaneh, H. El-Fawal, M. Rizig, M. Salama (Cairo, Egypt)

Microglial Activation and Phenotype in Air Pollution Neurotoxicity: Implications for Parkinson’s Disease

A. Tang-Tan, K. Shkirkova, A. Demetriou, S. Chen, C. Bent, L. Zhao, M. Thorwald, J. Godoy-Lugo, C. Sioutas, C. Pike, C. Finch, W. Mack (Los Angeles, USA)

Modeling Inflammation in GBA-Associated Parkinson’s Disease: Insights into Disease Mechanisms

V. Lentini, G. Uras, S. Lucas, D. Moreno-Martinez, A. Manca, F. Fierli, S. Koletsi, A. Pantaleo, D. Hughes (Sassari, Italy)

Moyamoya Disease and the Risk of Parkinson’s Disease

D. Yoo, J. Shin, R. Lee, J. Cheon, J. Kim, J. Won, I. Oh, Y. Lee, T. Ahn (Suwon, Republic of Korea)

Neuronal DJ-1 regulates microglia activation via ADAM10-mediated CX3CL1 secretion

A. Zhao, Y. Jiao, J. Liu, Y. Li (shanghai, China)

Neuroprotective Effects of ATP6V0C Overexpression in PFF Model Mice

Y. Wang, Y. Xia, L. Kou, T. Wang (wuhan, China)

Patient-specific Vascularized Midbrain Assembloids with Microglia show Altered Neuroinflammatory Phenotypes in Parkinson’s Disease

A-S. Zimmermann, S. Sabate-Soler, A. Zagare, J. Schwamborn (Belvaux, Luxembourg)

PINK1 activation improves outcomes in the UQCRC1 models of Parkinson’s disease

JL. Li, CC. Chan, CH. Lin (New Taipei City, Taiwan)

Preserved neuroplasticity in patients affected by Parkinson’s disease responders to auditory cueing strategies

L. Avanzino, A. Botta, V. Romano, J. Nonnekes, M. Gilat, I. Maidan, E. Pelosin (Genoa, Italy)

Profiling Neural Protein Dopaminylation in Parkinson’s disease

W. Chen, I. Maze (NEW YORK, USA)

Rescuing alpha-synuclein toxicity through neuron-specific enhancement of autophagy

J. Chua, M. Farah, S. Tewari, A. Parvataneni, V. Dawson, T. Dawson (Baltimore, USA)

Spatial Multi-Omics Identifies Early Synaptic Pruning and Context-Specific Dopaminergic Vulnerability in Synucleinopathies

S. Rumpf, F. Strübing, K. Nalbach, S. Lichtenthaler, C. Vargiu, P. Parchi, G. Höglinger, J. Herms, T. Koeglsperger (Munich, Germany)

Unveiling the Molecular Mechanism of Polydatin in Ameliorating Parkinson’s Disease via the DRD2/CRYAB/NF-κB Axis in Astrocytes and Exploring Cell Therapy Strategies

SJ. Peng, LP. Wang, YJ. Ou, RE. Liu (Beijing, China)

α-Synuclein Triggers Neuroinflammatory Damage through the suppression of MEF2C

X. Liu, E. Tao (Shenzhen, China)

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